1fsh: Difference between revisions

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[[Image:1fsh.gif|left|200px]]
{{Seed}}
[[Image:1fsh.png|left|200px]]


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{{STRUCTURE_1fsh|  PDB=1fsh  |  SCENE=  }}  
{{STRUCTURE_1fsh|  PDB=1fsh  |  SCENE=  }}  


'''STRUCTURAL BASIS OF THE RECOGNITION OF THE DISHEVELLED DEP DOMAIN IN THE WNT SIGNALING PATHWAY'''
===STRUCTURAL BASIS OF THE RECOGNITION OF THE DISHEVELLED DEP DOMAIN IN THE WNT SIGNALING PATHWAY===




==Overview==
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The DEP domain of Dishevelled (Dvl) proteins transduces signals to effector proteins downstream of Dvl in the Wnt pathway. Here we report that DEP-containing mutants inhibit Wnt-induced, but not Dvl-induced, activation of the transcription factor Lef-1. This inhibitory effect is weakened by a K434M mutation. Nuclear magnetic resonance spectroscopy revealed that the DEP domain of mouse Dvl1 comprises a three-helix bundle, a beta-hairpin 'arm' and two short beta-strands at the C-terminal region. Lys 434 is located at the tip of the beta-hairpin 'arm'. Based on our findings, we conclude that DEP interacts with regulators upstream of Dvl via a strong electric dipole on the molecule's surface created by Lys 434, Asp 445 and Asp 448; the electric dipole and the putative membrane binding site are at two different locations.
The line below this paragraph, {{ABSTRACT_PUBMED_11101902}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11101902 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11101902}}


==About this Structure==
==About this Structure==
1FSH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FSH OCA].  
1FSH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FSH OCA].  


==Reference==
==Reference==
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[[Category: Segment polarity protein dishevelled homolog dvl-1]]
[[Category: Segment polarity protein dishevelled homolog dvl-1]]
[[Category: Three-helix bundle]]
[[Category: Three-helix bundle]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:42:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:52:49 2008''
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