1fv3: Difference between revisions

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[[Image:1fv3.gif|left|200px]]
{{Seed}}
[[Image:1fv3.png|left|200px]]


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{{STRUCTURE_1fv3|  PDB=1fv3  |  SCENE=  }}  
{{STRUCTURE_1fv3|  PDB=1fv3  |  SCENE=  }}  


'''THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH AN ANALOGUE OF ITS GANGLIOSIDE RECEPTOR GT1B'''
===THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH AN ANALOGUE OF ITS GANGLIOSIDE RECEPTOR GT1B===




==Overview==
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Tetanus toxin, a member of the family of Clostridial neurotoxins, is one of the most potent toxins known. The crystal structure of the complex of the COOH-terminal fragment of the heavy chain with an analogue of its ganglioside receptor, GT1b, provides the first direct identification and characterization of the ganglioside-binding sites. The ganglioside induces cross-linking by binding to two distinct sites on the Hc molecule. The structure sheds new light on the binding of Clostridial neurotoxins to receptors on neuronal cells and provides important information relevant to the design of anti-tetanus and anti-botulism therapeutic agents.
The line below this paragraph, {{ABSTRACT_PUBMED_11418600}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11418600 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11418600}}


==About this Structure==
==About this Structure==
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[[Category: Receptor]]
[[Category: Receptor]]
[[Category: Toxin]]
[[Category: Toxin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:47:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:59:22 2008''
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