1fvt: Difference between revisions

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[[Image:1fvt.~~gif~~|left|200px]]

[[Image:1fvt.png|left|200px]]

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~~'''~~THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH AN OXINDOLE INHIBITOR~~'''~~

===THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH AN OXINDOLE INHIBITOR===

~~==Overview==~~

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~~Most traditional cytotoxic anticancer agents ablate~~ the ~~rapidly dividing epithelium of~~ the ~~hair follicle and induce alopecia~~ (~~hair loss)~~. ~~Inhibition of cyclin-dependent kinase 2 (CDK2~~), a positive regulator of eukaryotic cell cycle progression, may represent a therapeutic strategy for prevention of chemotherapy-induced alopecia (CIA) by arresting the cell cycle and reducing the sensitivity of the ~~epithelium to many cell cycle-active antitumor agents~~. ~~Potent small~~-~~molecule inhibitors of CDK2 were developed using structure~~-based methods. Topical application of these compounds in a neonatal rat model of CIA reduced hair loss at the site of application in 33 to 50% of the animals. Thus, inhibition of CDK2 represents a potentially useful approach for the prevention of CIA in cancer patients.

The line below this paragraph, {{ABSTRACT_PUBMED_11141566}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11141566 is the PubMed ID number.

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==About this Structure==

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[[Category: Cyclin-dependent kinase]]

[[Category: Oxindole]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 16~~:49:10 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:01:13 2008''

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-[[Image:1fvt.gif|left|200px]]
+{{Seed}}
+[[Image:1fvt.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1fvt|  PDB=1fvt  |  SCENE=  }}
-'''THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH AN OXINDOLE INHIBITOR'''
+===THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH AN OXINDOLE INHIBITOR===
-==Overview==
+<!--
-Most traditional cytotoxic anticancer agents ablate the rapidly dividing epithelium of the hair follicle and induce alopecia (hair loss). Inhibition of cyclin-dependent kinase 2 (CDK2), a positive regulator of eukaryotic cell cycle progression, may represent a therapeutic strategy for prevention of chemotherapy-induced alopecia (CIA) by arresting the cell cycle and reducing the sensitivity of the epithelium to many cell cycle-active antitumor agents. Potent small-molecule inhibitors of CDK2 were developed using structure-based methods. Topical application of these compounds in a neonatal rat model of CIA reduced hair loss at the site of application in 33 to 50% of the animals. Thus, inhibition of CDK2 represents a potentially useful approach for the prevention of CIA in cancer patients.
+The line below this paragraph, {{ABSTRACT_PUBMED_11141566}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11141566 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11141566}}
 ==About this Structure==
@@ Line 51: / Line 55: @@
 [[Category: Cyclin-dependent kinase]]
 [[Category: Oxindole]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:49:10 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 04:01:13 2008''