1fw8: Difference between revisions

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[[Image:1fw8.gif|left|200px]]
{{Seed}}
[[Image:1fw8.png|left|200px]]


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{{STRUCTURE_1fw8|  PDB=1fw8  |  SCENE=  }}  
{{STRUCTURE_1fw8|  PDB=1fw8  |  SCENE=  }}  


'''CIRCULARLY PERMUTED PHOSPHOGLYCERATE KINASE FROM YEAST: PGK P72'''
===CIRCULARLY PERMUTED PHOSPHOGLYCERATE KINASE FROM YEAST: PGK P72===




==Overview==
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The crystallographic structure of a circularly permuted form of yeast PGK, 72p yPGK, has been determined to a resolution of 2.3 A by molecular replacement. In this engineered protein, the C- and N-terminal residues of the wild-type protein are directly connected by a peptide bond and new N- and C-terminal residues are located within the N-terminal domain. The overall fold of the protein is very similar to that of the wild-type protein, directly demonstrating that the continuity of a folding unit is not relevant to the folding process of the whole protein. Only limited structural changes were observed: these were in the regions associated with the new connection, in a long flexible loop in the permuted domain and in the vicinity of Arg38, a functionally important residue. The relative positions of the two domains suggested that this permuted protein adopts one of the most open/twisted conformations seen amongst PGKs of known structure. The effect of the mutation on the functional properties is more easily accounted for by a restriction of hinge-bending motion than by structural changes in the protein.
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{{ABSTRACT_PUBMED_12454459}}


==About this Structure==
==About this Structure==
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[[Category: Phosphotransferase]]
[[Category: Phosphotransferase]]
[[Category: Protein folding,two-domain protein]]
[[Category: Protein folding,two-domain protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:50:10 2008''
 
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Revision as of 01:02, 1 July 2008

File:1fw8.png

Template:STRUCTURE 1fw8

CIRCULARLY PERMUTED PHOSPHOGLYCERATE KINASE FROM YEAST: PGK P72

Template:ABSTRACT PUBMED 12454459

About this Structure

1FW8 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of a circularly permuted phosphoglycerate kinase., Tougard P, Bizebard T, Ritco-Vonsovici M, Minard P, Desmadril M, Acta Crystallogr D Biol Crystallogr. 2002 Dec;58(Pt 12):2018-23. Epub 2002, Nov 23. PMID:12454459

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