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| {{STRUCTURE_1g3x| PDB=1g3x | SCENE= }} | | {{STRUCTURE_1g3x| PDB=1g3x | SCENE= }} |
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| '''INTERCALATION OF AN 9ACRIDINE-PEPTIDE DRUG IN A DNA DODECAMER'''
| | ===INTERCALATION OF AN 9ACRIDINE-PEPTIDE DRUG IN A DNA DODECAMER=== |
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| ==Overview==
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| We present the crystal structure of an acridine drug derivatized at carbon 9, [N(alpha)-(9-acridinoyl)-tetraarginine], intercalated within the dodecamer [d(CGCGAATTCGCG)](2). The presence of a lateral chain at the central carbon 9 atom differentiates this compound from most acridine drugs hitherto studied, which are usually derivatized at carbon 4. The DNA:drug interaction we observe differs from that observed in previous studies, which primarily involves shorter, mainly hexameric sequences, in two important regards: the acridine intercalates within an AA/TT base step, rather than within a CG/CG base step; and the binding site is located at the center of the sequence, rather than at one end of the duplex. In addition, we observe a novel crystal packing arrangement, with six dodecamer duplexes and seven hydrated magnesium ions in the asymmetric unit of a large (66.5 x 68.4 x 77.4 A(3)) unit cell in space group P2(1)2(1)2(1). The duplexes are organized in layers parallel to the ab plane, with consecutive layers crossing each other at right angles.
| | The line below this paragraph, {{ABSTRACT_PUBMED_12135355}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12135355 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_12135355}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Mg+2 ion]] | | [[Category: Mg+2 ion]] |
| [[Category: X-ray structure]] | | [[Category: X-ray structure]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:06:23 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:22:39 2008'' |
