1g6t: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,438 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,438 edits
No edit summary
Line 1: Line 1:
[[Image:1g6t.jpg|left|200px]]
{{Seed}}
[[Image:1g6t.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1g6t|  PDB=1g6t  |  SCENE=  }}  
{{STRUCTURE_1g6t|  PDB=1g6t  |  SCENE=  }}  


'''STRUCTURE OF EPSP SYNTHASE LIGANDED WITH SHIKIMATE-3-PHOSPHATE'''
===STRUCTURE OF EPSP SYNTHASE LIGANDED WITH SHIKIMATE-3-PHOSPHATE===




==Overview==
<!--
Biosynthesis of aromatic amino acids in plants, many bacteria, and microbes relies on the enzyme 5-enolpyruvylshikimate 3-phosphate (EPSP) synthase, a prime target for drugs and herbicides. We have identified the interaction of EPSP synthase with one of its two substrates (shikimate 3-phosphate) and with the widely used herbicide glyphosate by x-ray crystallography. The two-domain enzyme closes on ligand binding, thereby forming the active site in the interdomain cleft. Glyphosate appears to occupy the binding site of the second substrate of EPSP synthase (phosphoenol pyruvate), mimicking an intermediate state of the ternary enzyme.substrates complex. The elucidation of the active site of EPSP synthase and especially of the binding pattern of glyphosate provides a valuable roadmap for engineering new herbicides and herbicide-resistant crops, as well as new antibiotic and antiparasitic drugs.
The line below this paragraph, {{ABSTRACT_PUBMED_11171958}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11171958 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_11171958}}


==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Inside-out alpha-beta barrel]]
[[Category: Inside-out alpha-beta barrel]]
[[Category: Two-domain structure]]
[[Category: Two-domain structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:12:46 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:46:39 2008''
Retrieved from "https://proteopedia.org/1g6t"