1gea: Difference between revisions

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[[Image:1gea.gif|left|200px]]
{{Seed}}
[[Image:1gea.png|left|200px]]


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{{STRUCTURE_1gea|  PDB=1gea  |  SCENE=  }}  
{{STRUCTURE_1gea|  PDB=1gea  |  SCENE=  }}  


'''RECEPTOR-BOUND CONFORMATION OF PACAP21'''
===RECEPTOR-BOUND CONFORMATION OF PACAP21===




==Overview==
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Many peptide hormones elicit a wide array of physiological effects by binding to G-protein coupled receptors. We have determined the conformation of pituitary adenylate cyclase activating polypeptide, PACAP(1--21)NH(2), bound to a PACAP-specific receptor by NMR spectroscopy. Residues 3--7 form a unique beta-coil structure that is preceded by an N-terminal extended tail. This beta-coil creates a patch of hydrophobic residues that is important for receptor binding. In contrast, the C-terminal region (residues 8--21) forms an alpha-helix, similar to that in the micelle-bound PACAP. Thus, the conformational difference between PACAP in the receptor-bound and the micelle-bound states is limited to the N-terminal seven residues. This observation is consistent with the two-step ligand transportation model in which PACAP first binds to the membrane nonspecifically and then diffuses two-dimensionally in search of its receptor; a conformational change at the N-terminal region then allows specific interactions between the ligand and the receptor.
The line below this paragraph, {{ABSTRACT_PUBMED_11175907}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11175907 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11175907}}


==About this Structure==
==About this Structure==
1GEA is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GEA OCA].  
1GEA is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GEA OCA].  


==Reference==
==Reference==
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[[Category: Type-i beta turn]]
[[Category: Type-i beta turn]]
[[Category: Type-ii beta turn]]
[[Category: Type-ii beta turn]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:27:57 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:09:44 2008''

Revision as of 02:09, 1 July 2008

File:1gea.png

Template:STRUCTURE 1gea

RECEPTOR-BOUND CONFORMATION OF PACAP21

Template:ABSTRACT PUBMED 11175907

About this Structure

1GEA is a Single protein structure. Full experimental information is available from OCA.

Reference

Conformation of a peptide ligand bound to its G-protein coupled receptor., Inooka H, Ohtaki T, Kitahara O, Ikegami T, Endo S, Kitada C, Ogi K, Onda H, Fujino M, Shirakawa M, Nat Struct Biol. 2001 Feb;8(2):161-5. PMID:11175907

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