1ghf: Difference between revisions

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[[Image:1ghf.gif|left|200px]]
{{Seed}}
[[Image:1ghf.png|left|200px]]


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{{STRUCTURE_1ghf|  PDB=1ghf  |  SCENE=  }}  
{{STRUCTURE_1ghf|  PDB=1ghf  |  SCENE=  }}  


'''ANTI-ANTI-IDIOTYPE GH1002 FAB FRAGMENT'''
===ANTI-ANTI-IDIOTYPE GH1002 FAB FRAGMENT===




==Overview==
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The structure of the Fab fragment of the mouse anti-anti-idiotypic monoclonal antibody (mAb) GH1002 was solved by X-ray crystallography. mAb GH1002 was elicited with the syngeneic anti-idiotype mAb MK2-23 which mimics the determinant defined by anti-human high molecular weight-melanoma associated antigen (HMW-MAA) mAb 763.74. The Fab fragments of mAb GH1002 exist in the crystal as dimers related by crystallographic 2-fold axes. The interface between dyad-related Fab fragments is formed primarily by interaction of the hypervariable loops of one with the other. The self-interaction of Fab fragments of anti-anti-idiotypic mAb GH1002 through their combining sites is extremely tight and intricate, closely resembling that observed in structures of id-anti-id complexes, and comparable in terms of total contact area, charge complementarity, and number of hydrogen bonds. The self-complementarity of the antibody observed here could be coincidental and thus reflect some non-specific binding capability. It might, on the other hand, be immunologically relevant and exemplify a certain degree of evolved self complementarity characteristic of antibodies participating in idiotypic cascades.
The line below this paragraph, {{ABSTRACT_PUBMED_8568901}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_8568901}}


==About this Structure==
==About this Structure==
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[[Category: Wang, X.]]
[[Category: Wang, X.]]
[[Category: Antibody fab fragment]]
[[Category: Antibody fab fragment]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:33:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:17:27 2008''

Revision as of 02:17, 1 July 2008

File:1ghf.png

Template:STRUCTURE 1ghf

ANTI-ANTI-IDIOTYPE GH1002 FAB FRAGMENT

Template:ABSTRACT PUBMED 8568901

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of an anti-anti-idiotype shows it to be self-complementary., Ban N, Day J, Wang X, Ferrone S, McPherson A, J Mol Biol. 1996 Feb 2;255(4):617-27. PMID:8568901

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