1ghq: Difference between revisions

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[[Image:1ghq.jpg|left|200px]]
{{Seed}}
[[Image:1ghq.png|left|200px]]


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{{STRUCTURE_1ghq|  PDB=1ghq  |  SCENE=  }}  
{{STRUCTURE_1ghq|  PDB=1ghq  |  SCENE=  }}  


'''CR2-C3D COMPLEX STRUCTURE'''
===CR2-C3D COMPLEX STRUCTURE===




==Overview==
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Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design.
The line below this paragraph, {{ABSTRACT_PUBMED_11387479}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11387479 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11387479}}


==About this Structure==
==About this Structure==
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[[Category: C3d]]
[[Category: C3d]]
[[Category: Cr2]]
[[Category: Cr2]]
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