1gl2: Difference between revisions

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[[Image:1gl2.jpg|left|200px]]
{{Seed}}
[[Image:1gl2.png|left|200px]]


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{{STRUCTURE_1gl2|  PDB=1gl2  |  SCENE=  }}  
{{STRUCTURE_1gl2|  PDB=1gl2  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF AN ENDOSOMAL SNARE CORE COMPLEX'''
===CRYSTAL STRUCTURE OF AN ENDOSOMAL SNARE CORE COMPLEX===




==Overview==
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SNARE proteins are crucial for intracellular membrane fusion in all eukaryotes. These proteins assemble into tight complexes that connect membranes and may induce fusion. The crystal structure of the neuronal core complex is represented by an unusually long bundle of four alpha-helices connected by 16 layers of mostly hydrophobic amino acids. Here we report the 1.9 A resolution crystal structure of an endosomal SNARE core complex containing four SNAREs: syntaxin 7, syntaxin 8, vti1b and endobrevin/VAMP-8. Despite limited sequence homology, the helix alignment and the layer structure of the endosomal complex are remarkably similar to those of the neuronal complex. However, subtle variations are evident that characterize different SNARE subfamilies. We conclude that the structure of the SNARE core complex is an evolutionarily conserved hallmark of all SNARE complexes and is intimately associated with the general role of SNAREs in membrane fusion.
The line below this paragraph, {{ABSTRACT_PUBMED_11786915}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11786915 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11786915}}


==About this Structure==
==About this Structure==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Transport]]
[[Category: Transport]]
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