1go5: Difference between revisions

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[[Image:1go5.~~jpg~~|left|200px]]

[[Image:1go5.png|left|200px]]

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~~'''~~STRUCTURE OF THE C-TERMINAL FG-BINDING DOMAIN OF HUMAN TAP~~'''~~

===STRUCTURE OF THE C-TERMINAL FG-BINDING DOMAIN OF HUMAN TAP===

~~==Overview==~~

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The ~~vertebrate Tap protein is a member of~~ the ~~NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding~~ to ~~FG repeat-containing nuclear pore proteins~~ (~~FG-nucleoporins~~) ~~and is sufficient to mediate nuclear shuttling. We report the solution structure of this C-terminal domain~~, ~~which is based on a distinctive arrangement of four alpha-helices and~~ is ~~joined to~~ the ~~next module by a flexible 12-residue Pro-rich linker~~. ~~F617A Tap suppresses FG~~-~~nucleoporin binding by the most C~~-~~terminal domain that, together with the structure of the other modules from which Tap is constructed, provides a structural context for its nuclear shuttling function.~~

The line below this paragraph, {{ABSTRACT_PUBMED_11875519}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11875519 is the PubMed ID number.

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==About this Structure==

1GO5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GO5 OCA].

1GO5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GO5 OCA].

==Reference==

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[[Category: Nucleoporin]]

[[Category: Uba]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 17~~:48:46 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:35:25 2008''

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-[[Image:1go5.jpg|left|200px]]
+{{Seed}}
+[[Image:1go5.png|left|200px]]
 <!--
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 {{STRUCTURE_1go5|  PDB=1go5  |  SCENE=  }}
-'''STRUCTURE OF THE C-TERMINAL FG-BINDING DOMAIN OF HUMAN TAP'''
+===STRUCTURE OF THE C-TERMINAL FG-BINDING DOMAIN OF HUMAN TAP===
-==Overview==
+<!--
-The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling. We report the solution structure of this C-terminal domain, which is based on a distinctive arrangement of four alpha-helices and is joined to the next module by a flexible 12-residue Pro-rich linker. F617A Tap suppresses FG-nucleoporin binding by the most C-terminal domain that, together with the structure of the other modules from which Tap is constructed, provides a structural context for its nuclear shuttling function.
+The line below this paragraph, {{ABSTRACT_PUBMED_11875519}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11875519 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11875519}}
 ==About this Structure==
-GO5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GO5 OCA].
+GO5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GO5 OCA].
 ==Reference==
@@ Line 30: / Line 34: @@
 [[Category: Nucleoporin]]
 [[Category: Uba]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 17:48:46 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 05:35:25 2008''