1gp6: Difference between revisions

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[[Image:1gp6.jpg|left|200px]]
{{Seed}}
[[Image:1gp6.png|left|200px]]


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{{STRUCTURE_1gp6|  PDB=1gp6  |  SCENE=  }}  
{{STRUCTURE_1gp6|  PDB=1gp6  |  SCENE=  }}  


'''ANTHOCYANIDIN SYNTHASE FROM ARABIDOPSIS THALIANA COMPLEXED WITH TRANS-DIHYDROQUERCETIN (WITH 30 MIN EXPOSURE TO O2)'''
===ANTHOCYANIDIN SYNTHASE FROM ARABIDOPSIS THALIANA COMPLEXED WITH TRANS-DIHYDROQUERCETIN (WITH 30 MIN EXPOSURE TO O2)===




==Overview==
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Flavonoids are common colorants in plants and have long-established biomedicinal properties. Anthocyanidin synthase (ANS), a 2-oxoglutarate iron-dependent oxygenase, catalyzes the penultimate step in the biosynthesis of the anthocyanin class of flavonoids. The crystal structure of ANS reveals a multicomponent active site containing metal, cosubstrate, and two molecules of a substrate analog (dihydroquercetin). An additional structure obtained after 30 min exposure to dioxygen is consistent with the oxidation of the dihydroquercetin to quercetin and the concomitant decarboxylation of 2-oxoglutarate to succinate. Together with in vitro studies, the crystal structures suggest a mechanism for ANS-catalyzed anthocyanidin formation from the natural leucoanthocyanidin substrates involving stereoselective C-3 hydroxylation. The structure of ANS provides a template for the ubiquitous family of plant nonhaem oxygenases for future engineering and inhibition studies.
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{{ABSTRACT_PUBMED_11796114}}


==About this Structure==
==About this Structure==
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[[Category: 2-oxoglutarate dependent dioxygenase]]
[[Category: 2-oxoglutarate dependent dioxygenase]]
[[Category: Flavonoid biosynthesis]]
[[Category: Flavonoid biosynthesis]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:50:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:38:00 2008''
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