1gpr: Difference between revisions

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[[Image:1gpr.gif|left|200px]]
{{Seed}}
[[Image:1gpr.png|left|200px]]


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{{STRUCTURE_1gpr|  PDB=1gpr  |  SCENE=  }}  
{{STRUCTURE_1gpr|  PDB=1gpr  |  SCENE=  }}  


'''REFINED CRYSTAL STRUCTURE OF IIA DOMAIN OF THE GLUCOSE PERMEASE OF BACILLUS SUBTILIS AT 1.9 ANGSTROMS RESOLUTION'''
===REFINED CRYSTAL STRUCTURE OF IIA DOMAIN OF THE GLUCOSE PERMEASE OF BACILLUS SUBTILIS AT 1.9 ANGSTROMS RESOLUTION===




==Overview==
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The high resolution crystal structures of two interacting proteins from the phosphoenolpyruvate:sugar phosphotransferase system, the histidine-containing phosphocarrier protein (HPr) and the IIA domain of glucose permease (IIA(Glc)) from Bacillus subtilis, provide the basis for modeling the transient binary complex formed during the phosphoryl group transfer. The complementarity of the interacting surfaces implies that no major conformational transition is required. The negatively charged phosphoryl group is buried in the interface, suggesting a key role for electrostatic interactions. It is proposed that the phosphoryl transfer is triggered by a switch between two salt bridges involving Arg-17 of the HPr. The first, prior to phosphoryl group transfer, is intramolecular, with the phosphorylated His-15. The second, during the transfer, is intermolecular, with 2 aspartate residues associated with the active site of IIA(Glc). Such alternating ion pairs may be mechanistically important in other protein-protein phosphotransfer reactions.
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{{ABSTRACT_PUBMED_1447219}}


==About this Structure==
==About this Structure==
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[[Category: Liao, D I.]]
[[Category: Liao, D I.]]
[[Category: Phosphotransferase]]
[[Category: Phosphotransferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:52:01 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:41:22 2008''

Revision as of 02:41, 1 July 2008

File:1gpr.png

Template:STRUCTURE 1gpr

REFINED CRYSTAL STRUCTURE OF IIA DOMAIN OF THE GLUCOSE PERMEASE OF BACILLUS SUBTILIS AT 1.9 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 1447219

About this Structure

1GPR is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

An atomic model for protein-protein phosphoryl group transfer., Herzberg O, J Biol Chem. 1992 Dec 5;267(34):24819-23. PMID:1447219

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