1grw: Difference between revisions

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[[Image:1grw.gif|left|200px]]
{{Seed}}
[[Image:1grw.png|left|200px]]


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{{STRUCTURE_1grw|  PDB=1grw  |  SCENE=  }}  
{{STRUCTURE_1grw|  PDB=1grw  |  SCENE=  }}  


'''C. ELEGANS MAJOR SPERM PROTEIN'''
===C. ELEGANS MAJOR SPERM PROTEIN===




==Overview==
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The amoeboid locomotion of nematode sperm is mediated by the assembly dynamics of the major sperm protein (MSP). MSP forms fibrous networks based on a hierarchy of macromolecular assemblies: helical subfilaments are built from MSP dimers; filaments are formed from two subfilaments coiling round one another; and filaments themselves supercoil to produce bundles. To provide a structural context for understanding the role of these macromolecular assemblies in cell locomotion, we have determined the 2.6 A resolution structure of crystals of Caenorhabditis elegans MSP that are constructed from helices of MSP chains that are analogous to the subfilaments from which filaments are constructed. Comparison with the crystal structures of dimers and helical assemblies of Ascaris suum MSP has identified five conserved interaction interfaces that suggest how subfilaments interact in filaments and how filaments can form bundles. The interfaces frequently involve the loop containing residues 78-85, which is divergent between MSP homologues, and the loop containing residues 98-103, which is highly conserved.
The line below this paragraph, {{ABSTRACT_PUBMED_12051923}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12051923 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12051923}}


==About this Structure==
==About this Structure==
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[[Category: Cytosketal protein]]
[[Category: Cytosketal protein]]
[[Category: Sperm]]
[[Category: Sperm]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:56:11 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:58:27 2008''

Revision as of 02:58, 1 July 2008

File:1grw.png

Template:STRUCTURE 1grw

C. ELEGANS MAJOR SPERM PROTEIN

Template:ABSTRACT PUBMED 12051923

About this Structure

1GRW is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

2.6 A resolution crystal structure of helices of the motile major sperm protein (MSP) of Caenorhabditis elegans., Baker AM, Roberts TM, Stewart M, J Mol Biol. 2002 May 31;319(2):491-9. PMID:12051923

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