1grz: Difference between revisions

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[[Image:1grz.gif|left|200px]]
{{Seed}}
[[Image:1grz.png|left|200px]]


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{{STRUCTURE_1grz|  PDB=1grz  |  SCENE=  }}  
{{STRUCTURE_1grz|  PDB=1grz  |  SCENE=  }}  


'''A PREORGANIZED ACTIVE SITE IN THE CRYSTAL STRUCTURE OF THE TETRAHYMENA RIBOZYME'''
===A PREORGANIZED ACTIVE SITE IN THE CRYSTAL STRUCTURE OF THE TETRAHYMENA RIBOZYME===




==Overview==
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Group I introns possess a single active site that catalyzes the two sequential reactions of self-splicing. An RNA comprising the two domains of the Tetrahymena thermophila group I intron catalytic core retains activity, and the 5.0 angstrom crystal structure of this 247-nucleotide ribozyme is now described. Close packing of the two domains forms a shallow cleft capable of binding the short helix that contains the 5' splice site. The helix that provides the binding site for the guanosine substrate deviates significantly from A-form geometry, providing a tight binding pocket. The binding pockets for both the 5' splice site helix and guanosine are formed and oriented in the absence of these substrates. Thus, this large ribozyme is largely preorganized for catalysis, much like a globular protein enzyme.
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{{ABSTRACT_PUBMED_9841391}}


==About this Structure==
==About this Structure==
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[[Category: Ribozyme structure]]
[[Category: Ribozyme structure]]
[[Category: Rrna group i intron]]
[[Category: Rrna group i intron]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:56:18 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:58:38 2008''

Revision as of 02:58, 1 July 2008

File:1grz.png

Template:STRUCTURE 1grz

A PREORGANIZED ACTIVE SITE IN THE CRYSTAL STRUCTURE OF THE TETRAHYMENA RIBOZYME

Template:ABSTRACT PUBMED 9841391

About this Structure

Full crystallographic information is available from OCA.

Reference

A preorganized active site in the crystal structure of the Tetrahymena ribozyme., Golden BL, Gooding AR, Podell ER, Cech TR, Science. 1998 Oct 9;282(5387):259-64. PMID:9841391

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