1h18: Difference between revisions

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[[Image:1h18.jpg|left|200px]]
{{Seed}}
[[Image:1h18.png|left|200px]]


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{{STRUCTURE_1h18|  PDB=1h18  |  SCENE=  }}  
{{STRUCTURE_1h18|  PDB=1h18  |  SCENE=  }}  


'''PYRUVATE FORMATE-LYASE (E.COLI) IN COMPLEX WITH PYRUVATE'''
===PYRUVATE FORMATE-LYASE (E.COLI) IN COMPLEX WITH PYRUVATE===




==Overview==
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The glycyl radical enzyme pyruvate formate-lyase (PFL) synthesizes acetyl-CoA and formate from pyruvate and CoA. With the crystal structure of the non-radical form of PFL in complex with its two substrates, we have trapped the moment prior to pyruvate cleavage. The structure reveals how the active site aligns the scissile bond of pyruvate for radical attack, prevents non-radical side reactions of the pyruvate, and confines radical migration. The structure shows CoA in a syn conformation awaiting pyruvate cleavage. By changing to an anti conformation, without affecting the adenine binding mode of CoA, the thiol of CoA could pick up the acetyl group resulting from pyruvate cleavage.
The line below this paragraph, {{ABSTRACT_PUBMED_12163496}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12163496 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12163496}}


==About this Structure==
==About this Structure==
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[[Category: Lyase]]
[[Category: Lyase]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:17:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:27:14 2008''

Revision as of 03:27, 1 July 2008

File:1h18.png

Template:STRUCTURE 1h18

PYRUVATE FORMATE-LYASE (E.COLI) IN COMPLEX WITH PYRUVATE

Template:ABSTRACT PUBMED 12163496

About this Structure

1H18 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

X-ray structure of pyruvate formate-lyase in complex with pyruvate and CoA. How the enzyme uses the Cys-418 thiyl radical for pyruvate cleavage., Becker A, Kabsch W, J Biol Chem. 2002 Oct 18;277(42):40036-42. Epub 2002 Aug 5. PMID:12163496

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