|
|
| Line 1: |
Line 1: |
| [[Image:1h33.jpg|left|200px]] | | {{Seed}} |
| | [[Image:1h33.png|left|200px]] |
|
| |
|
| <!-- | | <!-- |
| Line 9: |
Line 10: |
| {{STRUCTURE_1h33| PDB=1h33 | SCENE= }} | | {{STRUCTURE_1h33| PDB=1h33 | SCENE= }} |
|
| |
|
| '''OXIDISED SOXAX COMPLEX FROM RHODOVULUM SULFIDOPHILUM'''
| | ===OXIDISED SOXAX COMPLEX FROM RHODOVULUM SULFIDOPHILUM=== |
|
| |
|
|
| |
|
| ==Overview==
| | <!-- |
| Reduced inorganic sulfur compounds are utilized by many bacteria as electron donors to photosynthetic or respiratory electron transport chains. This metabolism is a key component of the biogeochemical sulfur cycle. The SoxAX protein is a heterodimeric c-type cytochrome involved in thiosulfate oxidation. The crystal structures of SoxAX from the photosynthetic bacterium Rhodovulum sulfidophilum have been solved at 1.75 A resolution in the oxidized state and at 1.5 A resolution in the dithionite-reduced state, providing the first structural insights into the enzymatic oxidation of thiosulfate. The SoxAX active site contains a haem with unprecedented cysteine persulfide (cysteine sulfane) coordination. This unusual post-translational modification is also seen in sulfurtransferases such as rhodanese. Intriguingly, this enzyme shares further active site characteristics with SoxAX such as an adjacent conserved arginine residue and a strongly positive electrostatic potential. These similarities have allowed us to suggest a catalytic mechanism for enzymatic thiosulfate oxidation. The atomic coordinates and experimental structure factors have been deposited in the PDB with the accession codes 1H31, 1H32 and 1H33.
| | The line below this paragraph, {{ABSTRACT_PUBMED_12411478}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12411478 is the PubMed ID number. |
| | --> |
| | {{ABSTRACT_PUBMED_12411478}} |
|
| |
|
| ==About this Structure== | | ==About this Structure== |
| Line 34: |
Line 38: |
| [[Category: Sulfur cycle]] | | [[Category: Sulfur cycle]] |
| [[Category: Thiosulfate oxidation]] | | [[Category: Thiosulfate oxidation]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:22:05 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:32:39 2008'' |
