1h3o: Difference between revisions

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[[Image:1h3o.gif|left|200px]]
{{Seed}}
[[Image:1h3o.png|left|200px]]


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{{STRUCTURE_1h3o|  PDB=1h3o  |  SCENE=  }}  
{{STRUCTURE_1h3o|  PDB=1h3o  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE HUMAN TAF4-TAF12 (TAFII135-TAFII20) COMPLEX'''
===CRYSTAL STRUCTURE OF THE HUMAN TAF4-TAF12 (TAFII135-TAFII20) COMPLEX===




==Overview==
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The crystal structure is presented of a complex formed by the interacting domains from two subunits of the general transcription factor TFIID, the human TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20). In agreement with predictions, hTAF12 forms a histone fold that is very similar to that of histone H2B, yet unexpected differences are observed between the structures of the hTAF12 interaction domain of hTAF4 and histone H2A. Most importantly, the hTAF4 fragment forms only the first two helices of a classical histone fold, which are followed by a 26-residue disordered region. This indicates that either full-length TAF4 contains an unusually long connecting loop between its second and third helix, and this helix is not required for stable interaction with TAF12, or that TAF4 represents a novel class of partial histone fold motifs. Structural models and structure-based sequence alignments support a role for TAF4b and hSTAF42/yADA1 as alternative partners for TAF12 and are consistent with the formation of nucleosome-like histone-fold octamers through interaction of TAF12 with a TAF6-TAF9 tetramer, yet argue against involvement of TAF12-containing histone-fold pairs in DNA binding.
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{{ABSTRACT_PUBMED_12237304}}


==About this Structure==
==About this Structure==
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[[Category: Tbp-associated factor]]
[[Category: Tbp-associated factor]]
[[Category: Tfiid]]
[[Category: Tfiid]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:23:34 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:34:19 2008''

Revision as of 03:34, 1 July 2008

File:1h3o.png

Template:STRUCTURE 1h3o

CRYSTAL STRUCTURE OF THE HUMAN TAF4-TAF12 (TAFII135-TAFII20) COMPLEX

Template:ABSTRACT PUBMED 12237304

About this Structure

1H3O is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a subcomplex of human transcription factor TFIID formed by TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20)., Werten S, Mitschler A, Romier C, Gangloff YG, Thuault S, Davidson I, Moras D, J Biol Chem. 2002 Nov 22;277(47):45502-9. Epub 2002 Sep 16. PMID:12237304

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