1h6i: Difference between revisions

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[[Image:1h6i.gif|left|200px]]
{{Seed}}
[[Image:1h6i.png|left|200px]]


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{{STRUCTURE_1h6i|  PDB=1h6i  |  SCENE=  }}  
{{STRUCTURE_1h6i|  PDB=1h6i  |  SCENE=  }}  


'''A REFINED STRUCTURE OF HUMAN AQUAPORIN 1'''
===A REFINED STRUCTURE OF HUMAN AQUAPORIN 1===




==Overview==
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A refined structure of the human water channel aquaporin-1 is presented. The model rests on the high resolution X-ray structure of the homologous bacterial glycerol transporter GlpF, electron crystallographic data at 3.8 A resolution and a multiple sequence alignment of the aquaporin superfamily. The crystallographic R and free R values (36.7% and 37.8%) for the refined structure are significantly lower than for previous models. Improved geometry and enhanced stability in molecular dynamics simulations demonstrate a significant improvement of the aquaporin-1 structure. Comparison with previous aquaporin-1 models shows significant differences, not only in the loop regions, but also in the core of the water channel.
The line below this paragraph, {{ABSTRACT_PUBMED_11532455}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11532455}}


==About this Structure==
==About this Structure==
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[[Category: Two-dimensional crystal]]
[[Category: Two-dimensional crystal]]
[[Category: Water channel]]
[[Category: Water channel]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:29:42 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:42:14 2008''
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