1h8b: Difference between revisions

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[[Image:1h8b.gif|left|200px]]
{{Seed}}
[[Image:1h8b.png|left|200px]]


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{{STRUCTURE_1h8b|  PDB=1h8b  |  SCENE=  }}  
{{STRUCTURE_1h8b|  PDB=1h8b  |  SCENE=  }}  


'''EF-HANDS 3,4 FROM ALPHA-ACTININ / Z-REPEAT 7 FROM TITIN'''
===EF-HANDS 3,4 FROM ALPHA-ACTININ / Z-REPEAT 7 FROM TITIN===




==Overview==
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The interaction between alpha-actinin and titin, two modular muscle proteins, is essential for sarcomere assembly. We have solved the solution structure of a complex between the calcium-insensitive C-terminal EF-hand domain of alpha-actinin-2 and the seventh Z-repeat of titin. The structure of the complex is in a semi-open conformation and closely resembles that of myosin light chains in their complexes with heavy chain IQ motifs. However, no IQ motif is present in the Z-repeat, suggesting that the semi-open conformation is a general structural solution for calcium-independent recognition of EF-hand domains.
The line below this paragraph, {{ABSTRACT_PUBMED_11573089}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11573089 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11573089}}


==About this Structure==
==About this Structure==
1H8B is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8B OCA].  
1H8B is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8B OCA].  


==Reference==
==Reference==
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[[Category: Pastore, A.]]
[[Category: Pastore, A.]]
[[Category: Z-disk structural complex]]
[[Category: Z-disk structural complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:33:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:47:43 2008''

Revision as of 03:47, 1 July 2008

File:1h8b.png

Template:STRUCTURE 1h8b

EF-HANDS 3,4 FROM ALPHA-ACTININ / Z-REPEAT 7 FROM TITIN

Template:ABSTRACT PUBMED 11573089

About this Structure

1H8B is a Protein complex structure of sequences from Homo sapiens and Oryctolagus cuniculus. Full experimental information is available from OCA.

Reference

Ca2+-independent binding of an EF-hand domain to a novel motif in the alpha-actinin-titin complex., Atkinson RA, Joseph C, Kelly G, Muskett FW, Frenkiel TA, Nietlispach D, Pastore A, Nat Struct Biol. 2001 Oct;8(10):853-7. PMID:11573089

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