1ha1: Difference between revisions

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[[Image:1ha1.gif|left|200px]]
{{Seed}}
[[Image:1ha1.png|left|200px]]


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{{STRUCTURE_1ha1|  PDB=1ha1  |  SCENE=  }}  
{{STRUCTURE_1ha1|  PDB=1ha1  |  SCENE=  }}  


'''HNRNP A1 (RBD1,2) FROM HOMO SAPIENS'''
===HNRNP A1 (RBD1,2) FROM HOMO SAPIENS===




==Overview==
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Heterogeneous ribonucleoprotein A1 (hnRNP A1) is an abundant eukaryotic nuclear RNA binding protein. A1 is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm and may modulate splice site selection. The crystal structure of A1(RBD1,2) reveals two independently-folded RNA binding domains (RBDs) connected by a flexible linker. Both RBDs are structurally homologous to the U1A(RBD1), and have their RNA binding platforms oriented in an anti-parallel fashion. The anti-parallel arrangement of the A1 RNA binding platforms suggests mechanisms for RNA condensation and ways of bringing together distant RNA sequences for RNA metabolism such as splicing or transport.
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{{ABSTRACT_PUBMED_9164463}}


==About this Structure==
==About this Structure==
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[[Category: Rnp]]
[[Category: Rnp]]
[[Category: Rrm]]
[[Category: Rrm]]
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