1hbx: Difference between revisions

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[[Image:1hbx.~~gif~~|left|200px]]

[[Image:1hbx.png|left|200px]]

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~~'''~~TERNARY COMPLEX OF SAP-1 AND SRF WITH SPECIFIC SRE DNA~~'''~~

===TERNARY COMPLEX OF SAP-1 AND SRF WITH SPECIFIC SRE DNA===

~~==Overview==~~

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The ~~serum response element (SRE) is found in several immediate-early gene promoters. This DNA sequence is necessary and sufficient for rapid transcriptional induction of~~ the ~~human c-fos proto-oncogene in response to stimuli external~~ to the ~~cell~~. ~~Full activation of the SRE requires the cooperative binding of a ternary complex factor (TCF) and serum response factor (SRF) to their specific DNA sites~~. ~~The X-ray structure of the human SAP-1-SRF-SRE DNA ternary complex was determined (Protein Data Bank code 1hbx~~)~~. It shows SAP-1 TCF bound to SRF through interactions between~~ the ~~SAP-1 B-box and SRF MADS domain in addition to contacts between their respective DNA-binding motifs~~. ~~The SAP~~-~~1 B~~-box is part of a flexible linker of which 21 amino acids become ordered upon ternary complex formation. Comparison with a similar region from the yeast MATalpha2-MCM1-DNA complex suggests a common binding motif through which MADS-box proteins may interact with additional factors such as Fli-1.

The line below this paragraph, {{ABSTRACT_PUBMED_11406578}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11406578 is the PubMed ID number.

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==About this Structure==

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[[Category: Ternary complex factor]]

[[Category: Transcription complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 18~~:40:44 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 07:57:39 2008''

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-[[Image:1hbx.gif|left|200px]]
+{{Seed}}
+[[Image:1hbx.png|left|200px]]
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 {{STRUCTURE_1hbx|  PDB=1hbx  |  SCENE=  }}
-'''TERNARY COMPLEX OF SAP-1 AND SRF WITH SPECIFIC SRE DNA'''
+===TERNARY COMPLEX OF SAP-1 AND SRF WITH SPECIFIC SRE DNA===
-==Overview==
+<!--
-The serum response element (SRE) is found in several immediate-early gene promoters. This DNA sequence is necessary and sufficient for rapid transcriptional induction of the human c-fos proto-oncogene in response to stimuli external to the cell. Full activation of the SRE requires the cooperative binding of a ternary complex factor (TCF) and serum response factor (SRF) to their specific DNA sites. The X-ray structure of the human SAP-1-SRF-SRE DNA ternary complex was determined (Protein Data Bank code 1hbx). It shows SAP-1 TCF bound to SRF through interactions between the SAP-1 B-box and SRF MADS domain in addition to contacts between their respective DNA-binding motifs. The SAP-1 B-box is part of a flexible linker of which 21 amino acids become ordered upon ternary complex formation. Comparison with a similar region from the yeast MATalpha2-MCM1-DNA complex suggests a common binding motif through which MADS-box proteins may interact with additional factors such as Fli-1.
+The line below this paragraph, {{ABSTRACT_PUBMED_11406578}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11406578 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11406578}}
 ==About this Structure==
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 [[Category: Ternary complex factor]]
 [[Category: Transcription complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:40:44 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 07:57:39 2008''