1hcp: Difference between revisions

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[[Image:1hcp.gif|left|200px]]
{{Seed}}
[[Image:1hcp.png|left|200px]]


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{{STRUCTURE_1hcp|  PDB=1hcp  |  SCENE=  }}  
{{STRUCTURE_1hcp|  PDB=1hcp  |  SCENE=  }}  


'''DNA RECOGNITION BY THE OESTROGEN RECEPTOR: FROM SOLUTION TO THE CRYSTAL'''
===DNA RECOGNITION BY THE OESTROGEN RECEPTOR: FROM SOLUTION TO THE CRYSTAL===




==Overview==
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BACKGROUND: The steroid/nuclear hormone receptors are a large family of conserved ligand-activated transcription factors that regulate gene expression through binding to response elements upstream of their target genes. Most members of this family bind to DNA as homodimers or heterodimers and recognize the sequence, spacing and orientation of the two half-sites of their response elements. The recognition and discrimination of the sequence and arrangements of these half-sites are mediated primarily by a highly conserved DNA-binding domain. RESULTS: Here we describe the DNA-binding properties of the isolated DNA-binding domain of the oestrogen receptor, the ERDBD, and its refined NMR structure. This domain is monomeric in solution, but two molecules bind cooperatively to specific DNA sequences; this cooperativity determines the arrangement of half-sites that is recognized by the ERDBD. The 10 carboxy-terminal residues and a region of 15 residues within the domain are disordered in the solution structure, yet are important for DNA binding. CONCLUSION: The cooperative nature of ERDBD binding to DNA is important. The previously-determined X-ray structure of the ERDBD dimer bound to DNA shows that the 15 internal residues disordered in solution make contact both with DNA and with the corresponding region of the other monomer. These results suggest that these residues become ordered during the process of binding to DNA, forming the dimer interface and thus contributing to the cooperative interaction between monomers.
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{{ABSTRACT_PUBMED_16100953}}


==About this Structure==
==About this Structure==
1HCP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCP OCA].  
1HCP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCP OCA].  


==Reference==
==Reference==
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[[Category: Schwabe, J W.R.]]
[[Category: Schwabe, J W.R.]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:42:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 07:59:44 2008''

Revision as of 04:59, 1 July 2008

File:1hcp.png

Template:STRUCTURE 1hcp

DNA RECOGNITION BY THE OESTROGEN RECEPTOR: FROM SOLUTION TO THE CRYSTAL

Template:ABSTRACT PUBMED 16100953

About this Structure

1HCP is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

DNA recognition by the oestrogen receptor: from solution to the crystal., Schwabe JW, Chapman L, Finch JT, Rhodes D, Neuhaus D, Structure. 1993 Nov 15;1(3):187-204. PMID:16100953

Page seeded by OCA on Tue Jul 1 07:59:44 2008

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