1hcw: Difference between revisions

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[[Image:1hcw.gif|left|200px]]
{{Seed}}
[[Image:1hcw.png|left|200px]]


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{{STRUCTURE_1hcw|  PDB=1hcw  |  SCENE=  }}  
{{STRUCTURE_1hcw|  PDB=1hcw  |  SCENE=  }}  


'''23-RESIDUE DESIGNED METAL-FREE PEPTIDE BASED ON THE ZINC FINGER DOMAINS, NMR, 35 STRUCTURES'''
===23-RESIDUE DESIGNED METAL-FREE PEPTIDE BASED ON THE ZINC FINGER DOMAINS, NMR, 35 STRUCTURES===




==Overview==
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Small proteins or protein domains generally require disulfide bridges or metal sites for their stabilization. Here it is shown that the beta beta alpha architecture of zinc fingers can be reproduced in a 23-residue polypeptide in the absence of metal ions. The sequence was obtained through an iterative design process. A key feature of the final design is the incorporation of a type II' beta turn to aid in beta-hairpin formation. Nuclear magnetic resonance analysis reveals that the alpha helix and beta hairpin are held together by a defined hydrophobic core. The availability of this structural template has implications for the development of functional polypeptides.
The line below this paragraph, {{ABSTRACT_PUBMED_8553067}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8553067 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8553067}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCW OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HCW OCA].  


==Reference==
==Reference==
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[[Category: Growth response protein]]
[[Category: Growth response protein]]
[[Category: Supersecondary motif]]
[[Category: Supersecondary motif]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:42:43 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:00:21 2008''

Revision as of 05:00, 1 July 2008

File:1hcw.png

Template:STRUCTURE 1hcw

23-RESIDUE DESIGNED METAL-FREE PEPTIDE BASED ON THE ZINC FINGER DOMAINS, NMR, 35 STRUCTURES

Template:ABSTRACT PUBMED 8553067

About this Structure

Full experimental information is available from OCA.

Reference

Design of a monomeric 23-residue polypeptide with defined tertiary structure., Struthers MD, Cheng RP, Imperiali B, Science. 1996 Jan 19;271(5247):342-5. PMID:8553067

Page seeded by OCA on Tue Jul 1 08:00:21 2008

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