1he8: Difference between revisions

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[[Image:1he8.gif|left|200px]]
{{Seed}}
[[Image:1he8.png|left|200px]]


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{{STRUCTURE_1he8|  PDB=1he8  |  SCENE=  }}  
{{STRUCTURE_1he8|  PDB=1he8  |  SCENE=  }}  


'''RAS G12V-PI 3-KINASE GAMMA COMPLEX'''
===RAS G12V-PI 3-KINASE GAMMA COMPLEX===




==Overview==
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Ras activation of phosphoinositide 3-kinase (PI3K) is important for survival of transformed cells. We find that PI3Kgamma is strongly and directly activated by H-Ras G12V in vivo or by GTPgammaS-loaded H-Ras in vitro. We have determined a crystal structure of a PI3Kgamma/Ras.GMPPNP complex. A critical loop in the Ras binding domain positions Ras so that it uses its switch I and switch II regions to bind PI3Kgamma. Mutagenesis shows that interactions with both regions are essential for binding PI3Kgamma. Ras also forms a direct contact with the PI3Kgamma catalytic domain. These unique Ras/PI3Kgamma interactions are likely to be shared by PI3Kalpha. The complex with Ras shows a change in the PI3K conformation that may represent an allosteric component of Ras activation.
The line below this paragraph, {{ABSTRACT_PUBMED_11136978}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11136978 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11136978}}


==About this Structure==
==About this Structure==
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[[Category: Ras-binding domain]]
[[Category: Ras-binding domain]]
[[Category: Second messenger generation]]
[[Category: Second messenger generation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:45:27 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:03:54 2008''

Revision as of 05:03, 1 July 2008

File:1he8.png

Template:STRUCTURE 1he8

RAS G12V-PI 3-KINASE GAMMA COMPLEX

Template:ABSTRACT PUBMED 11136978

About this Structure

1HE8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma., Pacold ME, Suire S, Perisic O, Lara-Gonzalez S, Davis CT, Walker EH, Hawkins PT, Stephens L, Eccleston JF, Williams RL, Cell. 2000 Dec 8;103(6):931-43. PMID:11136978

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