1hgc: Difference between revisions

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[[Image:1hgc.jpg|left|200px]]
{{Seed}}
[[Image:1hgc.png|left|200px]]


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{{STRUCTURE_1hgc|  PDB=1hgc  |  SCENE=  }}  
{{STRUCTURE_1hgc|  PDB=1hgc  |  SCENE=  }}  


'''HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN'''
===HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN===




==Overview==
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The origin of co-operativity in haemoglobin (Hb) resides in the reduced affinity of the T-state. T-state Hb crystals grown from polyethyleneglycol can be liganded without the molecule switching to the R high affinity state. X-ray analysis of T-state alpha-oxy Hb and T-state met Hb has identified the structural basis for reduced affinity. The nature of the chemical tension at the haem environment is different in the alpha and beta haems. There are small but definite structural changes associated with ligation in the T-state: these prove to be mostly in the same direction as the larger changes that occur in the T--&gt;R transition.
The line below this paragraph, {{ABSTRACT_PUBMED_1453464}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_1453464}}


==About this Structure==
==About this Structure==
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[[Category: Liddington, R.]]
[[Category: Liddington, R.]]
[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:49:25 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:09:15 2008''

Revision as of 05:09, 1 July 2008

File:1hgc.png

Template:STRUCTURE 1hgc

HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN

Template:ABSTRACT PUBMED 1453464

About this Structure

1HGC is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-state haemoglobins: T(alpha-oxy)haemoglobin and T(met)haemoglobin., Liddington R, Derewenda Z, Dodson E, Hubbard R, Dodson G, J Mol Biol. 1992 Nov 20;228(2):551-79. PMID:1453464

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