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| [[Image:1hio.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1hio| PDB=1hio | SCENE= }} | | {{STRUCTURE_1hio| PDB=1hio | SCENE= }} |
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| '''HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN, ALPHA CARBONS ONLY'''
| | ===HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN, ALPHA CARBONS ONLY=== |
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| ==Overview==
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| The structure of the octameric histone core of the nucleosome has been determined by x-ray crystallography to a resolution of 3.1 A. The histone octamer is a tripartite assembly in which a centrally located (H3-H4)2 tetramer is flanked by two H2A-H2B dimers. It has a complex outer surface; depending on the perspective, the structure appears as a wedge or as a flat disk. The disk represents the planar projection of a left-handed proteinaceous superhelix with approximately 28 A pitch. The diameter of the particle is 65 A and the length is 60 A at its maximum and approximately 10 A at its minimum extension; these dimensions are in agreement with those reported earlier by Klug et al. [Klug, A., Rhodes, D., Smith, J., Finch, J. T. & Thomas, J. O. (1980) Nature (London) 287, 509-516]. The folded histone chains are elongated rather than globular and are assembled in a characteristic "handshake" motif. The individual polypeptides share a common central structural element of the helix-loop-helix type, which we name the histone fold. | | The line below this paragraph, {{ABSTRACT_PUBMED_1946434}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 1946434 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_1946434}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Histone]] | | [[Category: Histone]] |
| [[Category: Nucleosome core]] | | [[Category: Nucleosome core]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:53:02 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:14:13 2008'' |
