1hme: Difference between revisions

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[[Image:1hme.gif|left|200px]]
{{Seed}}
[[Image:1hme.png|left|200px]]


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{{STRUCTURE_1hme|  PDB=1hme  |  SCENE=  }}  
{{STRUCTURE_1hme|  PDB=1hme  |  SCENE=  }}  


'''STRUCTURE OF THE HMG BOX MOTIF IN THE B-DOMAIN OF HMG1'''
===STRUCTURE OF THE HMG BOX MOTIF IN THE B-DOMAIN OF HMG1===




==Overview==
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The conserved, abundant chromosomal protein HMG1 consists of two highly homologous, folded, basic DNA-binding domains, each of approximately 80 amino acid residues, and an acidic C-terminal tail. Each folded domain represents an 'HMG box', a sequence motif recently recognized in certain sequence-specific DNA-binding proteins and which also occurs in abundant HMG1-like proteins that bind to DNA without sequence specificity. The HMG box is defined by a set of highly conserved residues (most distinctively aromatic and basic) and appears to define a novel DNA-binding structural motif. We have expressed the HMG box region of the B-domain of rat HMG1 (residues 88-164 of the intact protein) in Escherichia coli and we describe here the determination of its structure by 2D 1H-NMR spectroscopy. There are three alpha-helices (residues 13-29, 34-48 and 50-74), which together account for approximately 75% of the total residues and contain many of the conserved basic and aromatic residues. Strikingly, the molecule is L-shaped, the angle of approximately 80 degrees between the two arms being defined by a cluster of conserved, predominantly aromatic, residues. The distinctive shape of the HMG box motif, which is distinct from hitherto characterized DNA-binding motifs, may be significant in relation to its recognition of four-way DNA junctions.
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{{ABSTRACT_PUBMED_8467791}}


==About this Structure==
==About this Structure==
1HME is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HME OCA].  
1HME is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HME OCA].  


==Reference==
==Reference==
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[[Category: Weir, H M.]]
[[Category: Weir, H M.]]
[[Category: Dna-binding]]
[[Category: Dna-binding]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:00:52 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:23:55 2008''

Revision as of 05:23, 1 July 2008

File:1hme.png

Template:STRUCTURE 1hme

STRUCTURE OF THE HMG BOX MOTIF IN THE B-DOMAIN OF HMG1

Template:ABSTRACT PUBMED 8467791

About this Structure

1HME is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Structure of the HMG box motif in the B-domain of HMG1., Weir HM, Kraulis PJ, Hill CS, Raine AR, Laue ED, Thomas JO, EMBO J. 1993 Apr;12(4):1311-9. PMID:8467791

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