1hoc: Difference between revisions

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[[Image:1hoc.~~gif~~|left|200px]]

[[Image:1hoc.png|left|200px]]

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~~'''~~THE THREE-DIMENSIONAL STRUCTURE OF H-2DB AT 2.4 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ANTIGEN-DETERMINANT SELECTION~~'''~~

===THE THREE-DIMENSIONAL STRUCTURE OF H-2DB AT 2.4 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ANTIGEN-DETERMINANT SELECTION===

~~==Overview==~~

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~~Solution at 2.4 A resolution of the structure of H-2Db with the influenza virus peptide NP366~~-~~374 (ASNEN~~-~~METM) and comparison with the H-2Kb-VSV (RGY-VYQGL) structure allow description of the molecular details of MHC class I peptide binding interactions for mice of the H-2b haplotype~~, revealing a strategy that maximizes the repertoire of peptides than can be presented. The H-2Db cleft has a mouse-specific hydrophobic ridge that causes a compensatory arch in the backbone of the peptide, ~~exposing~~ the ~~arch residues~~ to ~~TCR contact and requiring~~ the ~~peptide to be~~ at ~~least 9 residues~~. ~~This ridge occurs in about 40% of~~ the ~~known murine D and L allelic molecules, classifying them as a structural subgroup~~.

The line below this paragraph, {{ABSTRACT_PUBMED_7506996}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 7506996 is the PubMed ID number.

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==About this Structure==

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[[Category: Zhang, W.]]

[[Category: Histocompatibility antigen]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 19~~:03~~:54~~ 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:28:03 2008''

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-[[Image:1hoc.gif|left|200px]]
+{{Seed}}
+[[Image:1hoc.png|left|200px]]
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 {{STRUCTURE_1hoc|  PDB=1hoc  |  SCENE=  }}
-'''THE THREE-DIMENSIONAL STRUCTURE OF H-2DB AT 2.4 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ANTIGEN-DETERMINANT SELECTION'''
+===THE THREE-DIMENSIONAL STRUCTURE OF H-2DB AT 2.4 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ANTIGEN-DETERMINANT SELECTION===
-==Overview==
+<!--
-Solution at 2.4 A resolution of the structure of H-2Db with the influenza virus peptide NP366-374 (ASNEN-METM) and comparison with the H-2Kb-VSV (RGY-VYQGL) structure allow description of the molecular details of MHC class I peptide binding interactions for mice of the H-2b haplotype, revealing a strategy that maximizes the repertoire of peptides than can be presented. The H-2Db cleft has a mouse-specific hydrophobic ridge that causes a compensatory arch in the backbone of the peptide, exposing the arch residues to TCR contact and requiring the peptide to be at least 9 residues. This ridge occurs in about 40% of the known murine D and L allelic molecules, classifying them as a structural subgroup.
+The line below this paragraph, {{ABSTRACT_PUBMED_7506996}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7506996 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7506996}}
 ==About this Structure==
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 [[Category: Zhang, W.]]
 [[Category: Histocompatibility antigen]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:03:54 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 08:28:03 2008''