1ht9: Difference between revisions

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[[Image:1ht9.gif|left|200px]]
{{Seed}}
[[Image:1ht9.png|left|200px]]


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{{STRUCTURE_1ht9|  PDB=1ht9  |  SCENE=  }}  
{{STRUCTURE_1ht9|  PDB=1ht9  |  SCENE=  }}  


'''DOMAIN SWAPPING EF-HANDS'''
===DOMAIN SWAPPING EF-HANDS===




==Overview==
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The structure of calbindin D(9k) with two substitutions was determined by X-ray crystallography at 1.8-A resolution. Unlike wild-type calbindin D(9k), which is a monomeric protein with two EF-hands, the structure of the mutated calbindin D(9k) reveals an intertwined dimer. In the dimer, two EF-hands of the monomers have exchanged places, and thus a 3D domain-swapped dimer has been formed. EF-hand I of molecule A is packed toward EF-hand II of molecule B and vice versa. The formation of a hydrophobic cluster, in a region linking the EF-hands, promotes the conversion of monomers to 3D domain-swapped dimers. We propose a mechanism by which domain swapping takes place via the apo form of calbindin D(9k). Once formed, the calbindin D(9k) dimers are remarkably stable, as with even larger misfolded aggregates like amyloids. Thus calbindin D(9k) dimers cannot be converted to monomers by dilution. However, heating can be used for conversion, indicating high energy barriers separating monomers from dimers.
The line below this paragraph, {{ABSTRACT_PUBMED_11316872}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11316872 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11316872}}


==About this Structure==
==About this Structure==
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[[Category: Ef-hand]]
[[Category: Ef-hand]]
[[Category: Folding]]
[[Category: Folding]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:12:29 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:38:48 2008''

Revision as of 05:38, 1 July 2008

File:1ht9.png

Template:STRUCTURE 1ht9

DOMAIN SWAPPING EF-HANDS

Template:ABSTRACT PUBMED 11316872

About this Structure

1HT9 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

An extended hydrophobic core induces EF-hand swapping., Hakansson M, Svensson A, Fast J, Linse S, Protein Sci. 2001 May;10(5):927-33. PMID:11316872

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