1hv6: Difference between revisions

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[[Image:1hv6.~~gif~~|left|200px]]

[[Image:1hv6.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF ALGINATE LYASE A1-III COMPLEXED WITH TRISACCHARIDE PRODUCT.~~'''~~

===CRYSTAL STRUCTURE OF ALGINATE LYASE A1-III COMPLEXED WITH TRISACCHARIDE PRODUCT.===

~~==Overview==~~

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~~The structure of A1-III from a Sphingomonas species A1 complexed with a trisaccharide product (4~~-~~deoxy~~-~~l-erythro-hex-4-enepyranosyluronate-mannuronate-mannuronic acid) was determined by X-ray crystallography at 2.0 A with an R-factor of 0.16.~~ The ~~final model of the complex form comprising 351 amino acid residues~~, ~~245 water molecules~~, ~~one sulfate ion and one trisaccharide product exhibited a C~~(~~alpha) r~~.m.~~s.d. value of 0.154 A with~~ the ~~reported apo form of the enzyme~~. ~~The trisaccharide was bound in the active cleft at subsites~~ -~~3 approximately~~ -1 from the non-reducing end by forming several hydrogen bonds and van der Waals interactions with protein atoms. The catalytic residue was estimated to be Tyr246, which existed between subsites -1 and +1 based on a mannuronic acid model oriented at subsite +1.

The line below this paragraph, {{ABSTRACT_PUBMED_11243798}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11243798 is the PubMed ID number.

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==About this Structure==

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[[Category: Alginate lyase]]

[[Category: Trisaccharide complex,alpha barrel]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 19~~:15:50 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:49:25 2008''

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-[[Image:1hv6.gif|left|200px]]
+{{Seed}}
+[[Image:1hv6.png|left|200px]]
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@@ Line 9: / Line 10: @@
 {{STRUCTURE_1hv6|  PDB=1hv6  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF ALGINATE LYASE A1-III COMPLEXED WITH TRISACCHARIDE PRODUCT.'''
+===CRYSTAL STRUCTURE OF ALGINATE LYASE A1-III COMPLEXED WITH TRISACCHARIDE PRODUCT.===
-==Overview==
+<!--
-The structure of A1-III from a Sphingomonas species A1 complexed with a trisaccharide product (4-deoxy-l-erythro-hex-4-enepyranosyluronate-mannuronate-mannuronic acid) was determined by X-ray crystallography at 2.0 A with an R-factor of 0.16. The final model of the complex form comprising 351 amino acid residues, 245 water molecules, one sulfate ion and one trisaccharide product exhibited a C(alpha) r.m.s.d. value of 0.154 A with the reported apo form of the enzyme. The trisaccharide was bound in the active cleft at subsites -3 approximately -1 from the non-reducing end by forming several hydrogen bonds and van der Waals interactions with protein atoms. The catalytic residue was estimated to be Tyr246, which existed between subsites -1 and +1 based on a mannuronic acid model oriented at subsite +1.
+The line below this paragraph, {{ABSTRACT_PUBMED_11243798}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11243798 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11243798}}
 ==About this Structure==
@@ Line 29: / Line 33: @@
 [[Category: Alginate lyase]]
 [[Category: Trisaccharide complex,alpha barrel]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:15:50 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 08:49:25 2008''