1hvb: Difference between revisions

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[[Image:1hvb.gif|left|200px]]
{{Seed}}
[[Image:1hvb.png|left|200px]]


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{{STRUCTURE_1hvb|  PDB=1hvb  |  SCENE=  }}  
{{STRUCTURE_1hvb|  PDB=1hvb  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF STREPTOMYCES R61 DD-PEPTIDASE COMPLEXED WITH A NOVEL CEPHALOSPORIN ANALOG OF CELL WALL PEPTIDOGLYCAN'''
===CRYSTAL STRUCTURE OF STREPTOMYCES R61 DD-PEPTIDASE COMPLEXED WITH A NOVEL CEPHALOSPORIN ANALOG OF CELL WALL PEPTIDOGLYCAN===




==Overview==
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The cell wall imparts structural strength and shape to bacteria. It is made up of polymeric glycan chains with peptide branches that are cross-linked to form the cell wall. The cross-linking reaction, catalyzed by transpeptidases, is the last step in cell wall biosynthesis. These enzymes are members of the family of penicillin-binding proteins, the targets of beta-lactam antibiotics. We report herein the structure of a penicillin-binding protein complexed with a cephalosporin designed to probe the mechanism of the cross-linking reaction catalyzed by transpeptidases. The 1.2-A resolution x-ray structure of this cephalosporin bound to the active site of the bifunctional serine type D-alanyl-D-alanine carboxypeptidase/transpeptidase (EC ) from Streptomyces sp. strain R61 reveals how the two peptide strands from the polymeric substrates are sequestered in the active site of a transpeptidase. The structure of this complex provides a snapshot of the enzyme and the bound cell wall components poised for the final and critical cross-linking step of cell wall biosynthesis.
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{{ABSTRACT_PUBMED_11171967}}


==About this Structure==
==About this Structure==
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[[Category: Silvaggi, N R.]]
[[Category: Silvaggi, N R.]]
[[Category: Protein-cephalosporin complex]]
[[Category: Protein-cephalosporin complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:16:10 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:50:48 2008''

Revision as of 05:50, 1 July 2008

File:1hvb.png

Template:STRUCTURE 1hvb

CRYSTAL STRUCTURE OF STREPTOMYCES R61 DD-PEPTIDASE COMPLEXED WITH A NOVEL CEPHALOSPORIN ANALOG OF CELL WALL PEPTIDOGLYCAN

Template:ABSTRACT PUBMED 11171967

About this Structure

1HVB is a Single protein structure of sequence from Streptomyces sp.. Full crystallographic information is available from OCA.

Reference

A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis., Lee W, McDonough MA, Kotra L, Li ZH, Silvaggi NR, Takeda Y, Kelly JA, Mobashery S, Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1427-31. PMID:11171967

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