1hxv: Difference between revisions

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[[Image:1hxv.gif|left|200px]]
{{Seed}}
[[Image:1hxv.png|left|200px]]


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{{STRUCTURE_1hxv|  PDB=1hxv  |  SCENE=  }}  
{{STRUCTURE_1hxv|  PDB=1hxv  |  SCENE=  }}  


'''PPIASE DOMAIN OF THE MYCOPLASMA GENITALIUM TRIGGER FACTOR'''
===PPIASE DOMAIN OF THE MYCOPLASMA GENITALIUM TRIGGER FACTOR===




==Overview==
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We have solved the solution structure of the peptidyl-prolyl cis-trans isomerase (PPIase) domain of the trigger factor from Mycoplasma genitalium by homo- and heteronuclear NMR spectroscopy. Our results lead to a well-defined structure with a backbone rmsd of 0.23 A. As predicted, the PPIase domain of the trigger factor adopts the FK506 binding protein (FKBP) fold. Furthermore, our NMR relaxation data indicate that the dynamic behavior of the trigger factor PPIase domain and of FKBP are similar. Structural variations when compared to FKBP exist in the flap region and within the bulges of strand 5 of the beta sheet. Although the active-site crevice is similar to that of FKBP, subtle steric variations in this region can explain why FK506 does not bind to the trigger factor. Sequence variability (27% identity) between trigger factor and FKBP results in significant differences in surface charge distribution and the absence of the first strand of the central beta sheet. Our data indicate, however, that this strand may be partially structured as "nascent" beta strand. This makes the trigger factor PPIase domain the most minimal representative of the FKBP like protein family of PPIases.
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{{ABSTRACT_PUBMED_12054805}}


==About this Structure==
==About this Structure==
1HXV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycoplasma_genitalium Mycoplasma genitalium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HXV OCA].  
1HXV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycoplasma_genitalium Mycoplasma genitalium]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HXV OCA].  


==Reference==
==Reference==
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[[Category: Fkbp fold]]
[[Category: Fkbp fold]]
[[Category: Ppiase]]
[[Category: Ppiase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:20:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:06:08 2008''

Revision as of 07:06, 1 July 2008

File:1hxv.png

Template:STRUCTURE 1hxv

PPIASE DOMAIN OF THE MYCOPLASMA GENITALIUM TRIGGER FACTOR

Template:ABSTRACT PUBMED 12054805

About this Structure

1HXV is a Single protein structure of sequence from Mycoplasma genitalium. Full experimental information is available from OCA.

Reference

NMR solution structure and dynamics of the peptidyl-prolyl cis-trans isomerase domain of the trigger factor from Mycoplasma genitalium compared to FK506-binding protein., Vogtherr M, Jacobs DM, Parac TN, Maurer M, Pahl A, Saxena K, Ruterjans H, Griesinger C, Fiebig KM, J Mol Biol. 2002 May 10;318(4):1097-115. PMID:12054805

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