1i1a: Difference between revisions

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[[Image:1i1a.gif|left|200px]]
{{Seed}}
[[Image:1i1a.png|left|200px]]


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{{STRUCTURE_1i1a|  PDB=1i1a  |  SCENE=  }}  
{{STRUCTURE_1i1a|  PDB=1i1a  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE NEONATAL FC RECEPTOR COMPLEXED WITH A HETERODIMERIC FC'''
===CRYSTAL STRUCTURE OF THE NEONATAL FC RECEPTOR COMPLEXED WITH A HETERODIMERIC FC===




==Overview==
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The neonatal Fc receptor (FcRn) transports immunoglobulin G (IgG) across epithelia, binding IgG in acidic vesicles (pH &lt; or = 6.5) and releasing IgG in the blood at pH 7.4. Well-ordered FcRn/Fc crystals are prevented by the formation of "oligomeric ribbons" of FcRn dimers bridged by Fc homodimers, thus we crystallized a 1:1 complex between rat FcRn and a heterodimeric Fc containing only one FcRn binding site. The 2.8 A complex structure demonstrates that FcRn uses its alpha2 and beta2-microglobulin domains and carbohydrate to interact with the Fc C(gamma)2-C(gamma)3 interface. The structure reveals conformational changes in Fc and three titratable salt bridges that confer pH-dependent binding, and can be used to guide rational design of therapeutic IgGs with longer serum half-lives.
The line below this paragraph, {{ABSTRACT_PUBMED_11336709}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11336709 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11336709}}


==About this Structure==
==About this Structure==
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[[Category: Ig constant domain]]
[[Category: Ig constant domain]]
[[Category: Mhc class i fold]]
[[Category: Mhc class i fold]]
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