1i1e: Difference between revisions

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[[Image:1i1e.gif|left|200px]]
{{Seed}}
[[Image:1i1e.png|left|200px]]


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{{STRUCTURE_1i1e|  PDB=1i1e  |  SCENE=  }}  
{{STRUCTURE_1i1e|  PDB=1i1e  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN B COMPLEXED WITH DOXORUBICIN'''
===CRYSTAL STRUCTURE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN B COMPLEXED WITH DOXORUBICIN===




==Overview==
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The neurotoxins of Clostridium botulinum and tetanus bind to gangliosides as a first step of their toxin activity. Identifying suitable receptors that compete with gangliosides could prevent toxin binding to the neuronal cells. A possible ganglioside-binding site of the botulinum neurotoxin B (BoNT/B) has already been proposed and evidence is now presented for a drug binding to botulinum neurotoxin B from structural studies. Doxorubicin, a well known DNA intercalator, binds to the neurotoxin at the receptor-binding site proposed earlier. The structure of the BoNT/B-doxorubicin complex reveals that doxorubicin has interactions with the neurotoxin similar to those of sialyllactose. The aglycone moiety of the doxorubicin stacks with tryptophan 1261 and interacts with histidine 1240 of the binding domain. Here, the possibility is presented of designing a potential antagonist for these neurotoxins from crystallographic analysis of the neurotoxin-doxorubicin complex, which will be an excellent lead compound.
The line below this paragraph, {{ABSTRACT_PUBMED_11679763}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11679763 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11679763}}


==About this Structure==
==About this Structure==
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[[Category: Metalloprotease]]
[[Category: Metalloprotease]]
[[Category: Neurotoxin]]
[[Category: Neurotoxin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:27:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:16:12 2008''

Revision as of 07:16, 1 July 2008

File:1i1e.png

Template:STRUCTURE 1i1e

CRYSTAL STRUCTURE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN B COMPLEXED WITH DOXORUBICIN

Template:ABSTRACT PUBMED 11679763

About this Structure

1I1E is a Single protein structure of sequence from Clostridium botulinum. Full crystallographic information is available from OCA.

Reference

Crystallographic evidence for doxorubicin binding to the receptor-binding site in Clostridium botulinum neurotoxin B., Eswaramoorthy S, Kumaran D, Swaminathan S, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1743-6. Epub 2001, Oct 25. PMID:11679763

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