1i3h: Difference between revisions

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[[Image:1i3h.gif|left|200px]]
{{Seed}}
[[Image:1i3h.png|left|200px]]


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{{STRUCTURE_1i3h|  PDB=1i3h  |  SCENE=  }}  
{{STRUCTURE_1i3h|  PDB=1i3h  |  SCENE=  }}  


'''CONCANAVALIN A-DIMANNOSE STRUCTURE'''
===CONCANAVALIN A-DIMANNOSE STRUCTURE===




==Overview==
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The complex between concanavalin A (Con A) and alpha1-2 mannobiose (mannose alpha1-2 mannose) has been refined to 1.2 A resolution. This is the highest resolution structure reported for any sugar-lectin complex. As the native structure of Con A to 0.94 A resolution is already in the database, this gives us a unique opportunity to examine sugar-protein binding at high resolution. These data have allowed us to model a number of hydrogen atoms involved in the binding of the sugar to Con A, using the difference density map to place the hydrogen atoms. This map reveals the presence of the protonated form of Asp208 involved in binding. Asp208 is not protonated in the 0.94 A native structure. Our results clearly show that this residue is protonated and hydrogen bonds to the sugar. The structure accounts for the higher affinity of the alpha1-2 linked sugar when compared to other disaccharides. This structure identifies different interactions to those predicted by previous modelling studies. We believe that the additional data presented here will enable significant improvements to be made to the sugar-protein modelling algorithms.
The line below this paragraph, {{ABSTRACT_PUBMED_11453694}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11453694 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11453694}}


==About this Structure==
==About this Structure==
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[[Category: Concanavalin some]]
[[Category: Concanavalin some]]
[[Category: Protein-sugar complex]]
[[Category: Protein-sugar complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:31:41 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:21:29 2008''

Revision as of 07:21, 1 July 2008

File:1i3h.png

Template:STRUCTURE 1i3h

CONCANAVALIN A-DIMANNOSE STRUCTURE

Template:ABSTRACT PUBMED 11453694

About this Structure

1I3H is a Single protein structure of sequence from Canavalia ensiformis. Full crystallographic information is available from OCA.

Reference

The 1.2 A resolution structure of the Con A-dimannose complex., Sanders DA, Moothoo DN, Raftery J, Howard AJ, Helliwell JR, Naismith JH, J Mol Biol. 2001 Jul 20;310(4):875-84. PMID:11453694

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