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| {{STRUCTURE_1i9b| PDB=1i9b | SCENE= }} | | {{STRUCTURE_1i9b| PDB=1i9b | SCENE= }} |
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| '''X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP)'''
| | ===X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP)=== |
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| ==Overview==
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| Pentameric ligand gated ion-channels, or Cys-loop receptors, mediate rapid chemical transmission of signals. This superfamily of allosteric transmembrane proteins includes the nicotinic acetylcholine (nAChR), serotonin 5-HT3, gamma-aminobutyric-acid (GABAA and GABAC) and glycine receptors. Biochemical and electrophysiological information on the prototypic nAChRs is abundant but structural data at atomic resolution have been missing. Here we present the crystal structure of molluscan acetylcholine-binding protein (AChBP), a structural and functional homologue of the amino-terminal ligand-binding domain of an nAChR alpha-subunit. In the AChBP homopentamer, the protomers have an immunoglobulin-like topology. Ligand-binding sites are located at each of five subunit interfaces and contain residues contributed by biochemically determined 'loops' A to F. The subunit interfaces are highly variable within the ion-channel family, whereas the conserved residues stabilize the protomer fold. This AChBP structure is relevant for the development of drugs against, for example, Alzheimer's disease and nicotine addiction.
| | The line below this paragraph, {{ABSTRACT_PUBMED_11357122}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 11357122 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_11357122}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Igg fold]] | | [[Category: Igg fold]] |
| [[Category: Pentamer]] | | [[Category: Pentamer]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:43:57 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:37:01 2008'' |
