1ial: Difference between revisions

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[[Image:1ial.~~gif~~|left|200px]]

[[Image:1ial.png|left|200px]]

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~~'''~~IMPORTIN ALPHA, MOUSE~~'''~~

===IMPORTIN ALPHA, MOUSE===

~~==Overview==~~

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Importin alpha is the nuclear import receptor that recognizes classical monopartite and bipartite nuclear localization signals (NLSs). The structure of mouse importin alpha has been determined at 2.5 A resolution. The structure shows a large C-~~terminal domain containing armadillo repeats, and a less structured N~~-~~terminal importin beta-binding domain containing an internal NLS bound to the NLS-binding site.~~ The ~~structure explains the regulatory switch between the cytoplasmic~~, ~~high-affinity form~~, ~~and~~ the ~~nuclear, low-affinity form for NLS binding of~~ the ~~nuclear import receptor predicted by the current models of nuclear import~~. ~~Importin beta conceivably converts the low- to high-affinity form by binding to a site overlapping the autoinhibitory sequence~~. ~~The structure also has implications for understanding NLS recognition~~, ~~and~~ the ~~structures of armadillo and HEAT repeats~~.

The line below this paragraph, {{ABSTRACT_PUBMED_10201409}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10201409 is the PubMed ID number.

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==About this Structure==

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[[Category: Nuclear import receptor]]

[[Category: Nuclear localization signal]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 19~~:46:31 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:40:24 2008''

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-[[Image:1ial.gif|left|200px]]
+{{Seed}}
+[[Image:1ial.png|left|200px]]
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 {{STRUCTURE_1ial|  PDB=1ial  |  SCENE=  }}
-'''IMPORTIN ALPHA, MOUSE'''
+===IMPORTIN ALPHA, MOUSE===
-==Overview==
+<!--
-Importin alpha is the nuclear import receptor that recognizes classical monopartite and bipartite nuclear localization signals (NLSs). The structure of mouse importin alpha has been determined at 2.5 A resolution. The structure shows a large C-terminal domain containing armadillo repeats, and a less structured N-terminal importin beta-binding domain containing an internal NLS bound to the NLS-binding site. The structure explains the regulatory switch between the cytoplasmic, high-affinity form, and the nuclear, low-affinity form for NLS binding of the nuclear import receptor predicted by the current models of nuclear import. Importin beta conceivably converts the low- to high-affinity form by binding to a site overlapping the autoinhibitory sequence. The structure also has implications for understanding NLS recognition, and the structures of armadillo and HEAT repeats.
+The line below this paragraph, {{ABSTRACT_PUBMED_10201409}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10201409 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10201409}}
 ==About this Structure==
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 [[Category: Nuclear import receptor]]
 [[Category: Nuclear localization signal]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:46:31 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 10:40:24 2008''