1iap: Difference between revisions

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[[Image:1iap.jpg|left|200px]]
{{Seed}}
[[Image:1iap.png|left|200px]]


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{{STRUCTURE_1iap|  PDB=1iap  |  SCENE=  }}  
{{STRUCTURE_1iap|  PDB=1iap  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF P115RHOGEF RGRGS DOMAIN'''
===CRYSTAL STRUCTURE OF P115RHOGEF RGRGS DOMAIN===




==Overview==
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p115RhoGEF, a guanine nucleotide exchange factor for Rho GTPase, is also a GTPase activating protein (GAP) for G(12) and G(13) heterotrimeric G alpha subunits. Near its N-terminus, p115RhoGEF contains a domain (rgRGS) with remote sequence identity to RGS (regulators of G protein signaling) domains. The rgRGS domain is necessary but not sufficient for the GAP activity of p115RhoGEF. The 1.9 A resolution crystal structure of the rgRGS domain shows structural similarity to RGS domains but possesses a C-terminal extension that folds into a layer of helices that pack against the hydrophobic core of the domain. Mutagenesis experiments show that rgRGS may form interactions with G alpha(13) that are analogous to those in complexes of RGS proteins with their G alpha substrates.
The line below this paragraph, {{ABSTRACT_PUBMED_11524686}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11524686 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11524686}}


==About this Structure==
==About this Structure==
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[[Category: Rg]]
[[Category: Rg]]
[[Category: Rhogef]]
[[Category: Rhogef]]
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