1iar: Difference between revisions

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[[Image:1iar.jpg|left|200px]]
{{Seed}}
[[Image:1iar.png|left|200px]]


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{{STRUCTURE_1iar|  PDB=1iar  |  SCENE=  }}  
{{STRUCTURE_1iar|  PDB=1iar  |  SCENE=  }}  


'''INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX'''
===INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX===




==Overview==
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Interleukin-4 (IL-4) is a principal regulatory cytokine during an immune response and a crucial determinant for allergy and asthma. IL-4 binds with high affinity and specificity to the ectodomain of the IL-4 receptor alpha chain (IL4-BP). Subsequently, this intermediate complex recruits the common gamma chain (gamma c), thereby initiating transmembrane signaling. The crystal structure of the intermediate complex between human IL-4 and IL4-BP was determined at 2.3 A resolution. It reveals a novel spatial orientation of the two proteins, a small but unexpected conformational change in the receptor-bound IL-4, and an interface with three separate clusters of trans-interacting residues. Novel insights on ligand binding in the cytokine receptor family and a paradigm for receptors of IL-2, IL-7, IL-9, and IL-15, which all utilize gamma c, are provided.
The line below this paragraph, {{ABSTRACT_PUBMED_10219247}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10219247 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10219247}}


==About this Structure==
==About this Structure==
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[[Category: Sebald, W.]]
[[Category: Sebald, W.]]
[[Category: Cytokine receptor,interleukin-4]]
[[Category: Cytokine receptor,interleukin-4]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:46:54 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:40:51 2008''

Revision as of 07:40, 1 July 2008

File:1iar.png

Template:STRUCTURE 1iar

INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX

Template:ABSTRACT PUBMED 10219247

About this Structure

1IAR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface., Hage T, Sebald W, Reinemer P, Cell. 1999 Apr 16;97(2):271-81. PMID:10219247

Page seeded by OCA on Tue Jul 1 10:40:51 2008

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