1id9: Difference between revisions

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[[Image:1id9.gif|left|200px]]
{{Seed}}
[[Image:1id9.png|left|200px]]


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{{STRUCTURE_1id9|  PDB=1id9  |  SCENE=  }}  
{{STRUCTURE_1id9|  PDB=1id9  |  SCENE=  }}  


'''STRUCTURE OF THE HYBRID RNA/DNA R-GCUUCGGC-D[F]U IN PRESENCE OF RH(NH3)6+++'''
===STRUCTURE OF THE HYBRID RNA/DNA R-GCUUCGGC-D[F]U IN PRESENCE OF RH(NH3)6+++===




==Overview==
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In the presence of cobalt, rhodium or iridium hexammine salts, the RNA/DNA hybrid r-GCUUCGGC-d(X)U (with X = F, Cl or Br) crystallizes as a double-stranded helix with four consecutive G-U and C-U mismatches. The deoxy chloro- and bromouracil derivatives are isomorphous, space group C2, unit-cell parameters a = 53.80, b = 19.40, c = 50.31 A, beta = 109.9 degrees, with the same infinite helix arrangement in the packing along the c axis with one extra DNA halogenouracil base included in the stacking. However, the fluorouracil derivative, with unit-cell parameters a = 53.75, b = 19.40, c = 45.84 A, beta = 105.7 degrees, is not isomorphous. The corresponding extra DNA base d(F)U of the second strand is ejected out of the helical stack, leading to a shortening of the c axis. The specific destabilization of the fluorouracil for the duplex building is analyzed in terms of the polarization effect of the halogen atom attached to the 3'-terminal base that modulates its interactions.
The line below this paragraph, {{ABSTRACT_PUBMED_11679725}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11679725}}


==About this Structure==
==About this Structure==
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[[Category: G-u mismatch]]
[[Category: G-u mismatch]]
[[Category: Rna/dna hybrid]]
[[Category: Rna/dna hybrid]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:52:10 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:47:27 2008''

Revision as of 07:47, 1 July 2008

File:1id9.png

Template:STRUCTURE 1id9

STRUCTURE OF THE HYBRID RNA/DNA R-GCUUCGGC-D[F]U IN PRESENCE OF RH(NH3)6+++

Template:ABSTRACT PUBMED 11679725

About this Structure

Full crystallographic information is available from OCA.

Reference

Destabilizing effect of a fluorouracil extra base in a hybrid RNA duplex compared with bromo and chloro analogues., Cruse W, Saludjian P, Neuman A, Prange T, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1609-13. Epub 2001, Oct 25. PMID:11679725

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