1ien: Difference between revisions

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[[Image:1ien.~~gif~~|left|200px]]

[[Image:1ien.png|left|200px]]

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~~'''~~SOLUTION STRUCTURE OF TIA~~'''~~

===SOLUTION STRUCTURE OF TIA===

~~==Overview==~~

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~~Cone snails use venom containing a cocktail of peptides ('conopeptides') to capture their prey. Many of these peptides also target mammalian receptors~~, ~~often with exquisite selectivity. Here we report the discovery of two new classes of conopeptides. One class targets alpha1-adrenoceptors (rho-TIA from the fish-hunting Conus tulipa)~~, ~~and~~ the ~~second class targets~~ the ~~neuronal noradrenaline transporter~~ (~~chi-MrIA and chi-MrIB from the mollusk-hunting C~~. ~~marmoreus~~). ~~rho~~-~~TIA and chi~~-~~MrIA selectively modulate these important membrane-bound proteins. Both peptides act as reversible non-competitive inhibitors and provide alternative avenues for the identification of inhibitor drugs.~~

The line below this paragraph, {{ABSTRACT_PUBMED_11528421}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11528421 is the PubMed ID number.

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==About this Structure==

1IEN is a [[Single protein]] structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEN OCA].

1IEN is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEN OCA].

==Reference==

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[[Category: Alpha1-adrenoceptor]]

[[Category: Conotoxin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 19~~:55:06 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:51:18 2008''

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-[[Image:1ien.gif|left|200px]]
+{{Seed}}
+[[Image:1ien.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1ien|  PDB=1ien  |  SCENE=  }}
-'''SOLUTION STRUCTURE OF TIA'''
+===SOLUTION STRUCTURE OF TIA===
-==Overview==
+<!--
-Cone snails use venom containing a cocktail of peptides ('conopeptides') to capture their prey. Many of these peptides also target mammalian receptors, often with exquisite selectivity. Here we report the discovery of two new classes of conopeptides. One class targets alpha1-adrenoceptors (rho-TIA from the fish-hunting Conus tulipa), and the second class targets the neuronal noradrenaline transporter (chi-MrIA and chi-MrIB from the mollusk-hunting C. marmoreus). rho-TIA and chi-MrIA selectively modulate these important membrane-bound proteins. Both peptides act as reversible non-competitive inhibitors and provide alternative avenues for the identification of inhibitor drugs.
+The line below this paragraph, {{ABSTRACT_PUBMED_11528421}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11528421 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11528421}}
 ==About this Structure==
-IEN is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEN OCA].
+IEN is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEN OCA].
 ==Reference==
@@ Line 34: / Line 38: @@
 [[Category: Alpha1-adrenoceptor]]
 [[Category: Conotoxin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:55:06 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 10:51:18 2008''