1ifa: Difference between revisions

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[[Image:1ifa.jpg|left|200px]]
{{Seed}}
[[Image:1ifa.png|left|200px]]


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{{STRUCTURE_1ifa|  PDB=1ifa  |  SCENE=  }}  
{{STRUCTURE_1ifa|  PDB=1ifa  |  SCENE=  }}  


'''THREE-DIMENSIONAL CRYSTAL STRUCTURE OF RECOMBINANT MURINE INTERFERON-BETA'''
===THREE-DIMENSIONAL CRYSTAL STRUCTURE OF RECOMBINANT MURINE INTERFERON-BETA===




==Overview==
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The crystal structure of recombinant murine interferon-beta (IFN-beta) has been solved by the multiple isomorphous replacement method and refined to an R-factor of 20.5% against 2.6 A X-ray diffraction data. The structure shows a variant of the alpha-helix bundle with a new chain-folding topology, which seems to represent a basic structural framework of all the IFN-alpha and IFN-beta molecules belonging to the type I family. Functionally important segments of the polypeptide chain, as implied through numerous gene manipulation studies carried out so far, are spatially clustered indicating the binding site(s) to the receptor(s). Comparison of the present structure with those of other alpha-helical cytokine proteins, including porcine growth hormone, interleukin 2 and interferon gamma, indicated either a topological similarity in chain folding or a similar spatial arrangement of the alpha-helices.
The line below this paragraph, {{ABSTRACT_PUBMED_1505514}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 1505514 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1505514}}


==About this Structure==
==About this Structure==
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[[Category: Shimizu, H.]]
[[Category: Shimizu, H.]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:56:27 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:52:55 2008''

Revision as of 07:52, 1 July 2008

File:1ifa.png

Template:STRUCTURE 1ifa

THREE-DIMENSIONAL CRYSTAL STRUCTURE OF RECOMBINANT MURINE INTERFERON-BETA

Template:ABSTRACT PUBMED 1505514

About this Structure

1IFA is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Three-dimensional crystal structure of recombinant murine interferon-beta., Senda T, Shimazu T, Matsuda S, Kawano G, Shimizu H, Nakamura KT, Mitsui Y, EMBO J. 1992 Sep;11(9):3193-201. PMID:1505514

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