1ig7: Difference between revisions

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[[Image:1ig7.gif|left|200px]]
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[[Image:1ig7.png|left|200px]]


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{{STRUCTURE_1ig7|  PDB=1ig7  |  SCENE=  }}  
{{STRUCTURE_1ig7|  PDB=1ig7  |  SCENE=  }}  


'''Msx-1 Homeodomain/DNA Complex Structure'''
===Msx-1 Homeodomain/DNA Complex Structure===




==Overview==
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The Msx-1 homeodomain protein plays a crucial role in craniofacial, limb, and nervous system development. Homeodomain DNA-binding domains are comprised of 60 amino acids that show a high degree of evolutionary conservation. We have determined the structure of the Msx-1 homeodomain complexed to DNA at 2.2 A resolution. The structure has an unusually well-ordered N-terminal arm with a unique trajectory across the minor groove of the DNA. DNA specificity conferred by bases flanking the core TAAT sequence is explained by well ordered water-mediated interactions at Q50. Most interactions seen at the TAAT sequence are typical of the interactions seen in other homeodomain structures. Comparison of the Msx-1-HD structure to all other high resolution HD-DNA complex structures indicate a remarkably well-conserved sphere of hydration between the DNA and protein in these complexes.
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{{ABSTRACT_PUBMED_11580277}}


==About this Structure==
==About this Structure==
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[[Category: Hovde, S.]]
[[Category: Hovde, S.]]
[[Category: Helix-turn-helix]]
[[Category: Helix-turn-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:57:27 2008''

Revision as of 07:57, 1 July 2008

File:1ig7.png

Template:STRUCTURE 1ig7

Msx-1 Homeodomain/DNA Complex Structure

Template:ABSTRACT PUBMED 11580277

About this Structure

1IG7 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Msx-1 homeodomain/DNA complex., Hovde S, Abate-Shen C, Geiger JH, Biochemistry. 2001 Oct 9;40(40):12013-21. PMID:11580277

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