1ij1: Difference between revisions

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[[Image:1ij1.jpg|left|200px]]
{{Seed}}
[[Image:1ij1.png|left|200px]]


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{{STRUCTURE_1ij1|  PDB=1ij1  |  SCENE=  }}  
{{STRUCTURE_1ij1|  PDB=1ij1  |  SCENE=  }}  


'''GCN4-pVLT Coiled-coil Trimer with Threonine at the d(12) Position'''
===GCN4-pVLT Coiled-coil Trimer with Threonine at the d(12) Position===




==Overview==
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Coiled coils, estimated to constitute 3-5% of the encoded residues in most genomes, are characterized by a heptad repeat, (abcdefg)(n), where the buried a and d positions form the interface between multiple alpha-helices. Although generally hydrophobic, a substantial fraction ( approximately 20%) of these a- and d-position residues are polar or charged. We constructed variants of the well-characterized coiled coil GCN4-p1 with a single polar residue (Asn, Gln, Ser, or Thr) at either an a or a d position. The stability and oligomeric specificity of each variant were measured, and crystal structures of coiled-coil trimers with threonine or serine at either an a or a d position were determined. The structures show how single polar residues in the interface affect not only local packing, but also overall coiled-coil geometry as seen by changes in the Crick supercoil parameters and core cavity volumes.
The line below this paragraph, {{ABSTRACT_PUBMED_11371197}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11371197 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11371197}}


==About this Structure==
==About this Structure==
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[[Category: Coiled coil]]
[[Category: Coiled coil]]
[[Category: Gcn4]]
[[Category: Gcn4]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:03:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:18:19 2008''

Revision as of 09:18, 1 July 2008

File:1ij1.png

Template:STRUCTURE 1ij1

GCN4-pVLT Coiled-coil Trimer with Threonine at the d(12) Position

Template:ABSTRACT PUBMED 11371197

About this Structure

1IJ1 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Buried polar residues in coiled-coil interfaces., Akey DL, Malashkevich VN, Kim PS, Biochemistry. 2001 May 29;40(21):6352-60. PMID:11371197

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