1ijl: Difference between revisions

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[[Image:1ijl.jpg|left|200px]]
{{Seed}}
[[Image:1ijl.png|left|200px]]


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{{STRUCTURE_1ijl|  PDB=1ijl  |  SCENE=  }}  
{{STRUCTURE_1ijl|  PDB=1ijl  |  SCENE=  }}  


'''Crystal structure of acidic phospholipase A2 from deinagkistrodon acutus'''
===Crystal structure of acidic phospholipase A2 from deinagkistrodon acutus===




==Overview==
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An acidic phospholipase A(2) was purified from Deinagkistrodon acutus (Agkistrodon acutus) which displays an inhibitory effect on platelet aggregation. The three-dimensional structure of the enzyme was determined by molecular replacement at 2.6 A resolution with a crystallographic R factor of 18.40% (R(free) = 22.50%) and reasonable stereochemistry. Two molecules in the asymmetric unit form a dimer and the dimer formation accompanies a significant conformational adaptation of segment 14-23, a constituent of the 'interface recognition site' (IRS). This probably reflects the inherent structural flexibility of the IRS. The possible expansion of the site for inhibiting platelet aggregation as proposed previously [Wang et al. (1996), J. Mol. Biol. 255, 669-676] is discussed.
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{{ABSTRACT_PUBMED_11752784}}


==About this Structure==
==About this Structure==
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[[Category: One two strand beta sheet]]
[[Category: One two strand beta sheet]]
[[Category: Three long helix]]
[[Category: Three long helix]]
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