1ikf: Difference between revisions

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[[Image:1ikf.gif|left|200px]]
{{Seed}}
[[Image:1ikf.png|left|200px]]


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{{STRUCTURE_1ikf|  PDB=1ikf  |  SCENE=  }}  
{{STRUCTURE_1ikf|  PDB=1ikf  |  SCENE=  }}  


'''A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX'''
===A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX===




==Overview==
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The conformation of the immunosuppressive drug cyclosporin A (CsA) in a complex with a Fab molecule has been established by crystallographic analysis to 2.65 angstrom resolution. This conformation of CsA is similar to that recently observed in the complex with the rotamase cyclophilin, its binding protein in vivo, and totally different from its conformation in an isolated form as determined from x-ray and nuclear magnetic resonance analysis. Because the surfaces of CsA interacting with cyclophilin or with the Fab are not identical, these results suggest that the conformation of CsA observed in the bound form preexists in aqueous solution and is not produced by interaction with the proteins.
The line below this paragraph, {{ABSTRACT_PUBMED_1566062}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_1566062}}


==About this Structure==
==About this Structure==
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[[Category: Thierry, J C.]]
[[Category: Thierry, J C.]]
[[Category: Vix, O.]]
[[Category: Vix, O.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:05:57 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:23:03 2008''

Revision as of 10:23, 1 July 2008

File:1ikf.png

Template:STRUCTURE 1ikf

A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX

Template:ABSTRACT PUBMED 1566062

About this Structure

Full crystallographic information is available from OCA.

Reference

A conformation of cyclosporin A in aqueous environment revealed by the X-ray structure of a cyclosporin-Fab complex., Altschuh D, Vix O, Rees B, Thierry JC, Science. 1992 Apr 3;256(5053):92-4. PMID:1566062

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