1imv: Difference between revisions

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[[Image:1imv.gif|left|200px]]
{{Seed}}
[[Image:1imv.png|left|200px]]


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{{STRUCTURE_1imv|  PDB=1imv  |  SCENE=  }}  
{{STRUCTURE_1imv|  PDB=1imv  |  SCENE=  }}  


'''2.85 A crystal structure of PEDF'''
===2.85 A crystal structure of PEDF===




==Overview==
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Pigment epithelium-derived factor (PEDF), a noninhibitory member of the serpin superfamily, is the most potent inhibitor of angiogenesis in the mammalian ocular compartment. It also has neurotrophic activity, both in the retina and in the central nervous system, and is highly up-regulated in young versus senescent fibroblasts. To provide a structural basis for understanding its many biological roles, we have solved the crystal structure of glycosylated human PEDF to 2.85 A. The structure revealed the organization of possible receptor and heparin-binding sites, and showed that, unlike any other previously characterized serpin, PEDF has a striking asymmetric charge distribution that might be of functional importance. These results provide a starting point for future detailed structure/function analyses into possible mechanisms of PEDF action that could lead to development of therapeutics against uncontrolled angiogenesis.
The line below this paragraph, {{ABSTRACT_PUBMED_11562499}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11562499 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11562499}}


==About this Structure==
==About this Structure==
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[[Category: Pedf]]
[[Category: Pedf]]
[[Category: Serpin]]
[[Category: Serpin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:10:15 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:34:18 2008''

Revision as of 10:34, 1 July 2008

File:1imv.png

Template:STRUCTURE 1imv

2.85 A crystal structure of PEDF

Template:ABSTRACT PUBMED 11562499

About this Structure

1IMV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor., Simonovic M, Gettins PG, Volz K, Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11131-5. Epub 2001 Sep 18. PMID:11562499

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