1irk: Difference between revisions

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{{Seed}}
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{{STRUCTURE_1irk|  PDB=1irk  |  SCENE=  }}  
{{STRUCTURE_1irk|  PDB=1irk  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR'''
===CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR===




==Overview==
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The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.
The line below this paragraph, {{ABSTRACT_PUBMED_7997262}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_7997262}}


==About this Structure==
==About this Structure==
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[[Category: Hubbard, S R.]]
[[Category: Hubbard, S R.]]
[[Category: Wei, L.]]
[[Category: Wei, L.]]
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