1itg: Difference between revisions

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[[Image:1itg.~~gif~~|left|200px]]

[[Image:1itg.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES~~'''~~

===CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES===

~~==Overview==~~

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~~HIV integrase is~~ the ~~enzyme responsible for inserting~~ the ~~viral DNA into the host chromosome;~~ it ~~is essential for HIV replication. The crystal structure of the catalytically active core domain (residues 50 to 212) of HIV-1 integrase was determined~~ at 2.~~5 A resolution~~. ~~The central feature of the structure~~ is a five-stranded beta sheet flanked by helical regions. The overall topology reveals that this domain of integrase belongs to a superfamily of polynucleotidyl transferases that includes ribonuclease H and the ~~Holliday junction resolvase RuvC~~. The active site region is identified by the position of two of the conserved carboxylate residues essential for catalysis, which are located at similar positions in ribonuclease H. In the crystal, two molecules form a dimer with a extensive solvent-~~inaccessible interface of 1300 A2 per monomer.~~

The line below this paragraph, {{ABSTRACT_PUBMED_7801124}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 7801124 is the PubMed ID number.

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==About this Structure==

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[[Category: Jenkins, T M.]]

[[Category: Dna integration]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 20~~:23:38 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:58:15 2008''

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-[[Image:1itg.gif|left|200px]]
+{{Seed}}
+[[Image:1itg.png|left|200px]]
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 {{STRUCTURE_1itg|  PDB=1itg  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES'''
+===CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES===
-==Overview==
+<!--
-HIV integrase is the enzyme responsible for inserting the viral DNA into the host chromosome; it is essential for HIV replication. The crystal structure of the catalytically active core domain (residues 50 to 212) of HIV-1 integrase was determined at 2.5 A resolution. The central feature of the structure is a five-stranded beta sheet flanked by helical regions. The overall topology reveals that this domain of integrase belongs to a superfamily of polynucleotidyl transferases that includes ribonuclease H and the Holliday junction resolvase RuvC. The active site region is identified by the position of two of the conserved carboxylate residues essential for catalysis, which are located at similar positions in ribonuclease H. In the crystal, two molecules form a dimer with a extensive solvent-inaccessible interface of 1300 A2 per monomer.
+The line below this paragraph, {{ABSTRACT_PUBMED_7801124}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7801124 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7801124}}
 ==About this Structure==
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 [[Category: Jenkins, T M.]]
 [[Category: Dna integration]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:23:38 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 13:58:15 2008''